Pear pomace soluble dietary fiber suppresses fat deposition in high fat diet-fed mice by regulating the ADPN-AMPK/PPAR-α signaling pathway

Abstract

This study was amied to explore the molecular mechanisms of the effect of pear pomace soluble dietary fiber (PP-SDF) on weight gain, fat deposition and regulation of lipid metabolism in obese mice. The PP-SDF can positively modulate the adverse effects of obesity. In this study, the PP-SDF extracted via microbial fermentation was investigated for its weight loss mechanism in high-fat diet induced obese mice. Soluble dietary fiber was also investigated for the enzymes related to fat metabolism and for intervention to reduce adipose inflammation related to obesity. Furthermore, AMPK and PPAR-α signaling pathway related to ADPN were investigated and the key enzymes in the pathways were measured. The results show that PP-SDF regulated obesity-related metabolic disorders by inhibiting obesity inflammation and by activating AMPK/PPAR-α signaling pathway, while ADPN was the key target for the regulation of these two pathways.

Keywords

• Pear pomace soluble dietary fiber
• Inflammation
• ADPN-AMPK
• ADPN-PPAR-α
• Obesity