Protection of allergic rhinitis in mice via the colonic release of butyrate from butyrylated starch

Zhen Chen; Yang Liu; Chenyu Chen; Xing Lin; Yihan Wei; Qingqing Xu; Shancai He; Yuanteng Xu

Journal of Functional Foods (Apr 2024)

Protection of allergic rhinitis in mice via the colonic release of butyrate from butyrylated starch

Zhen Chen,
Yang Liu,
Chenyu Chen,
Xing Lin,
Yihan Wei,
Qingqing Xu,
Shancai He,
Yuanteng Xu

Affiliations

Zhen Chen: Department of Otorhinolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China; Department of Otorhinolaryngology-Head and Neck Surgery, National Regional Medical Center, Binhai Campus of The First Affiliated Hospital of Fujian Medical University, Fuzhou, China
Yang Liu: Department of Otorhinolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China; Department of Otorhinolaryngology-Head and Neck Surgery, National Regional Medical Center, Binhai Campus of The First Affiliated Hospital of Fujian Medical University, Fuzhou, China
Chenyu Chen: Department of Otorhinolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China; Department of Otorhinolaryngology-Head and Neck Surgery, National Regional Medical Center, Binhai Campus of The First Affiliated Hospital of Fujian Medical University, Fuzhou, China
Xing Lin: Department of Otorhinolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China; Department of Otorhinolaryngology-Head and Neck Surgery, National Regional Medical Center, Binhai Campus of The First Affiliated Hospital of Fujian Medical University, Fuzhou, China
Yihan Wei: Department of Otorhinolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China; Department of Otorhinolaryngology-Head and Neck Surgery, National Regional Medical Center, Binhai Campus of The First Affiliated Hospital of Fujian Medical University, Fuzhou, China
Qingqing Xu: Department of Otorhinolaryngology, Fujian Children's Hospital, Fuzhou, China
Shancai He: Department of Otorhinolaryngology, Fuqing City Hospital Affiliated to Fujian Medical University, Fuzhou, China
Yuanteng Xu: Department of Otorhinolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China; Department of Otorhinolaryngology-Head and Neck Surgery, National Regional Medical Center, Binhai Campus of The First Affiliated Hospital of Fujian Medical University, Fuzhou, China; Allergy Center, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China; Corresponding author.

Journal volume & issue: Vol. 115
p. 106115

Abstract

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Butyrate has potential beneficial effects on allergic rhinitis (AR). However, the effect of AR mice via the colonic butyrate is still unclear. We investigated the potential mechanism of colonic butyrate derived from butyrylated starch intervention to improve the atopy and regulate gut microbiota in AR mice. The results demonstrated that butyrylated starch significantly increased the levels of colonic butyrate, and downregulated serum OVA-sIgE, IL-4, and IL-5, and improved symptoms in AR mice. In addition, the proportion of Treg cells in mesenteric lymph nodes and the levels of IL-10 and TGF-β in the serum were elevated after butyrylated starch intervention. Moreover, butyrylated starch promoted the enrichment of beneficial genera in AR mice, such as Lactobacillus, and alleviated the composition and structural disorder of gut microbiota in AR mice. In conclusion, butyrylated starch demonstrated a preventive effect on AR, possibly by modulating the gut microbiota and promoting Treg cell function.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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