Betacyanins functionalized selenium nanoparticles inhibit HepG2 cells growth via mitochondria-mediated pathway

Xiang-Yi Tang; Shu-Juan Yu; Xiao-Ming Guo; He Li; Ming-Shun Chen; Tao Zhang; Cai-Yu Lei; Zhen-Gang Zhao; He-Cheng Meng

Journal of Functional Foods (Mar 2021)

Betacyanins functionalized selenium nanoparticles inhibit HepG2 cells growth via mitochondria-mediated pathway

Xiang-Yi Tang,
Shu-Juan Yu,
Xiao-Ming Guo,
He Li,
Ming-Shun Chen,
Tao Zhang,
Cai-Yu Lei,
Zhen-Gang Zhao,
He-Cheng Meng

Affiliations

Xiang-Yi Tang: School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China
Shu-Juan Yu: School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China; Overseas Expertise Introduction Center for Discipline Innovation of Food Nutrition and Human Health (111 Center), Guangzhou, China; Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety Guangzhou, China
Xiao-Ming Guo: School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China
He Li: School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China
Ming-Shun Chen: School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China
Tao Zhang: School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China
Cai-Yu Lei: School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China
Zhen-Gang Zhao: School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China; Overseas Expertise Introduction Center for Discipline Innovation of Food Nutrition and Human Health (111 Center), Guangzhou, China; Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety Guangzhou, China
He-Cheng Meng: School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China; Overseas Expertise Introduction Center for Discipline Innovation of Food Nutrition and Human Health (111 Center), Guangzhou, China; Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety Guangzhou, China; Corresponding author at: School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China.

Journal volume & issue: Vol. 78
p. 104359

Abstract

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Over the past few years, selenium nanoparticles (SeNPs)-mediated chemotherapy has aroused extensive attention for its low toxicity and high anti-tumor properties. However, the stability and anti-tumor properties of SeNPs require further improvement. In this study, betacyanin (Bc), a natural bioactive compound, was designed to decorate SeNPs with substantial anticancer efficacy. As revealed from the results, Bc-modified SeNPs (Bc@SeNPs) exhibited an average size of 133 nm and remained in a stable state for at least 1 month. Besides, the Bc@SeNPs exhibited a higher antioxidant activity and bioavailability compared with those of naked SeNPs. Moreover, Bc@SeNPs potentiated chemotherapy was demonstrated to exhibit superior in vitro anti-tumor efficacy against HepG2 hepatoma carcinoma cells, which could activate caspase cascade and induce mitochondria-mediated apoptosis. Overall, this study developed a novel strategy to increase the added value of red beet, and it was proved that Bc-functionalized SeNPs can act as potential chemotherapeutic agents for cancer therapy.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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