Novel Chlorella pyrenoidosa peptides attenuate weight gain, insulin resistance, and lipid levels in mice fed a high-fat diet

Wenxiang Liu; Wenjuan Shen; Peifang Weng; Zufang Wu; Yanan Liu

Journal of Functional Foods (Jan 2024)

Novel Chlorella pyrenoidosa peptides attenuate weight gain, insulin resistance, and lipid levels in mice fed a high-fat diet

Wenxiang Liu,
Wenjuan Shen,
Peifang Weng,
Zufang Wu,
Yanan Liu

Affiliations

Wenxiang Liu: Department of Food Science and Engineering, Zhejiang-Malaysia Joint Research Laboratory for Agri-cultural Product Processing and Nutrition, Zhejiang Provincial Key Laboratory of Animal Protein Food Intensive Processing Technology, Ningbo University, Ningbo, 315800, PR China
Wenjuan Shen: Department of Food Science and Engineering, Zhejiang-Malaysia Joint Research Laboratory for Agri-cultural Product Processing and Nutrition, Zhejiang Provincial Key Laboratory of Animal Protein Food Intensive Processing Technology, Ningbo University, Ningbo, 315800, PR China
Peifang Weng: Department of Food Science and Engineering, Zhejiang-Malaysia Joint Research Laboratory for Agri-cultural Product Processing and Nutrition, Zhejiang Provincial Key Laboratory of Animal Protein Food Intensive Processing Technology, Ningbo University, Ningbo, 315800, PR China
Zufang Wu: Department of Food Science and Engineering, Zhejiang-Malaysia Joint Research Laboratory for Agri-cultural Product Processing and Nutrition, Zhejiang Provincial Key Laboratory of Animal Protein Food Intensive Processing Technology, Ningbo University, Ningbo, 315800, PR China
Yanan Liu: Department of Food Science and Engineering, Zhejiang-Malaysia Joint Research Laboratory for Agri-cultural Product Processing and Nutrition, Zhejiang Provincial Key Laboratory of Animal Protein Food Intensive Processing Technology, Ningbo University, Ningbo, 315800, PR China; Ningbo Academy of Product and Food Quality Inspection (Ningbo Fiber Inspection Institute), Ningbo 315048, PR China; College of Food Science and Technology, Nanjing Agricultural University, Nanjing, 210095, PR China; Corresponding author at: Ningbo University, Ningbo 315800, PR China; Ningbo Academy of Product and Food Quality Inspection, Ningbo 315048, PR China; Nanjing Agricultural University, Nanjing, 210095,PR China.

Journal volume & issue: Vol. 112
p. 105908

Abstract

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Obesity can cause a wide range of metabolic diseases, but safe and effective treatments are still lacking. Chlorella pyrenoidosa (C. pyrenoidosa) peptides have a variety of biological activities, but their lipid-lowering effects in vivo are rarely reported. In this study, one (SISISVAGGGR, T1) of the six C. pyrenoidosa peptides with the best lipid-lowering and gut microbial stability maintenance was screened. Then, the anti-obesity effects of different doses of T1 (300 mg/Kg/d, 100 mg/Kg/d) were evaluated in mice fed a high-fat diet (HFD). The results showed that T1 supplementation alleviated HFD-induced weight gain and lipid accumulation, reduced fasting blood glucose and low-density lipoprotein (LDL) and elevated high-density lipoprotein (HDL) levels. T1 improved insulin resistance and attenuated hepatic lipid accumulation and meta-inflammation in both liver and adipose tissues in obese mice. This study demonstrated a novel C. pyrenoidosa peptide as a potential prebiotic with beneficial effects on obesity and related metabolic disorders.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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