Regulatory effects of a Grifola frondosa extract rich in pseudobaptigenin and cyanidin-3-O-xylosylrutinoside on glycolipid metabolism and the gut microbiota in high-fat diet-fed rats

Jiacong Deng; Weiling Guo; Jianbin Guo; Yan Li; Wenbin Zhou; Wenlong Lv; Lu Li; Bin Liu; Guizhi Xia; Li Ni; Pingfan Rao; Xucong Lv

Journal of Functional Foods (Dec 2020)

Regulatory effects of a Grifola frondosa extract rich in pseudobaptigenin and cyanidin-3-O-xylosylrutinoside on glycolipid metabolism and the gut microbiota in high-fat diet-fed rats

Jiacong Deng,
Weiling Guo,
Jianbin Guo,
Yan Li,
Wenbin Zhou,
Wenlong Lv,
Lu Li,
Bin Liu,
Guizhi Xia,
Li Ni,
Pingfan Rao,
Xucong Lv

Affiliations

Jiacong Deng: School of Ocean Science and Biochemistry Engineering, Fuqing Branch of Fujian Normal University, Fuqing, Fujian 350300, PR China
Weiling Guo: Institute of Food Science and Technology, College of Biological Science and Technology, Fuzhou University, Fuzhou, Fujian 350108, PR China; College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, PR China
Jianbin Guo: Fujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterial & Stomatological Key Lab of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, Fujian 350001, PR China
Yan Li: College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, PR China
Wenbin Zhou: Institute of Food Science and Technology, College of Biological Science and Technology, Fuzhou University, Fuzhou, Fujian 350108, PR China; College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, PR China
Wenlong Lv: Department of Radiation Oncology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, PR China
Lu Li: Institute of Food Science and Technology, College of Biological Science and Technology, Fuzhou University, Fuzhou, Fujian 350108, PR China; College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, PR China
Bin Liu: College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, PR China
Guizhi Xia: Department of Paediatrics, The 900th Hospital of Joint Logistic Support Force, PLA, Fuzhou, Fujian 350025, PR China; Corresponding authors at: Institute of Food Science and Technology, College of Biological Science and Engineering, Fuzhou University, Fuzhou, Fujian 350108, PR China (X. Lv).
Li Ni: Institute of Food Science and Technology, College of Biological Science and Technology, Fuzhou University, Fuzhou, Fujian 350108, PR China
Pingfan Rao: Institute of Food Science and Technology, College of Biological Science and Technology, Fuzhou University, Fuzhou, Fujian 350108, PR China
Xucong Lv: School of Ocean Science and Biochemistry Engineering, Fuqing Branch of Fujian Normal University, Fuqing, Fujian 350300, PR China; Institute of Food Science and Technology, College of Biological Science and Technology, Fuzhou University, Fuzhou, Fujian 350108, PR China; College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, PR China; Corresponding authors at: Institute of Food Science and Technology, College of Biological Science and Engineering, Fuzhou University, Fuzhou, Fujian 350108, PR China (X. Lv).

Journal volume & issue: Vol. 75
p. 104230

Abstract

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The aim of present study was to investigate the regulatory effects of an extract of the Grifola frondosa on glycolipid metabolism and the intestinal flora in high-fat diet fed rats. The ethyl acetate extract of G. frondosa (EAE), enriched with pseudobaptigenin and cyanidin 3-O-xylosylrutinoside, exerted a stronger inhibitory effect on lipase than the other polar fractions of G. frondosa in vitro. Supplementation with EAE (50 mg/kg) to rats for 8 weeks clearly ameliorated dyslipidaemia by suppressing the serum levels of glucose (Glu), total triglycerides (TG) and low-density lipoprotein cholesterol (LDL-C), and hepatic fat accumulation. Furthermore, EAE supplementation normalized the intestinal flora structure in high-fat diet fed rats. The relevance analysis suggested strong associations of Anaerotruncus, Barnesiella, Clostridiaceae, Erysipelotrichaceae, Paraprevotella, Clostridium_XVIII, Coprococcus and Turicibacter with the biochemical indexes. Simultaneously, the EAE treatment intervened the expression levels of the genes associated with glycolipid metabolism. Our results indicated that pseudobaptigenin and cyanidin-3-O-xylosylrutinoside can be used as pharmaceutical agents for the prevention of the disorder of glycolipid metabolism.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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