Propionylated high-amylose maize starch alleviates obesity by modulating gut microbiota in high-fat diet-fed mice

Zhuqing Xie; Minghua Yao; Josué L. Castro-Mejía; Ming Ma; Yuyan Zhu; Xiong Fu; Qiang Huang; Bin Zhang

Journal of Functional Foods (Mar 2023)

Propionylated high-amylose maize starch alleviates obesity by modulating gut microbiota in high-fat diet-fed mice

Zhuqing Xie,
Minghua Yao,
Josué L. Castro-Mejía,
Ming Ma,
Yuyan Zhu,
Xiong Fu,
Qiang Huang,
Bin Zhang

Affiliations

Zhuqing Xie: School of Food Science and Engineering, Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, South China University of Technology, Guangzhou 510640, China; Department of Food Science, University of Copenhagen, Rolighedsvej 26, 1958 Frederiksberg C, Denmark
Minghua Yao: Shanghai Jiaotong University School of Medicine, Shanghai General Hospital, Shanghai 200080, China; Corresponding authors at: School of Food Science and Engineering, Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, South China University of Technology, Guangzhou 510640, China (B.Z.).
Josué L. Castro-Mejía: Department of Food Science, University of Copenhagen, Rolighedsvej 26, 1958 Frederiksberg C, Denmark
Ming Ma: Shanghai Institute of Ceramics, Chinese Academy of Sciences, State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai 200050, China
Yuyan Zhu: Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China
Xiong Fu: School of Food Science and Engineering, Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, South China University of Technology, Guangzhou 510640, China
Qiang Huang: School of Food Science and Engineering, Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, South China University of Technology, Guangzhou 510640, China
Bin Zhang: School of Food Science and Engineering, Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, South China University of Technology, Guangzhou 510640, China; Overseas Expertise Introduction Center for Discipline Innovation of Food Nutrition and Human Health, South China University of Technology, Guangzhou 510640, China; Corresponding authors at: School of Food Science and Engineering, Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, South China University of Technology, Guangzhou 510640, China (B.Z.).

Journal volume & issue: Vol. 102
p. 105447

Abstract

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Obesity threatens human health worldwide, and mounting findings have found that gut microbiota (GM) changes induced by diet intervention influence its development. This study aims to investigate the anti-obesity effects and GM changes of propionylated high-amylose maize starch (PS) in C57BL/6J mice fed with high-fat diet (HFD). In our results, PS decreased the body weight of HFD-fed mice after 8 weeks and regulated the glucose stability and insulin resistance. High-amylose maize starch (HAMS) and PS regulated the serum lipid levels and inflammatory response. Moreover, PS yielded more propionate relative to HAMS, proving that introduced propionyl groups could be released in the colon. 16S rRNA results showed that PS altered GM with the increase of bacteria (S24-7 and Ruminococcus) and decrease of harmful genera, which is linked to the anti-obesity effect. Our results provide a reference for the design of functional dietary fibers inducing high propionate production and GM modulation.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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