Bioactive constituents from Vitex negundo var. heterophylla and their antioxidant and α-glucosidase inhibitory activities

Ping Hu; Da-Hong Li; Cui-Cui Jia; Quan Liu; Xiao-Fei Wang; Zhan-Lin Li; Hui-Ming Hua

Journal of Functional Foods (Aug 2017)

Bioactive constituents from Vitex negundo var. heterophylla and their antioxidant and α-glucosidase inhibitory activities

Ping Hu,
Da-Hong Li,
Cui-Cui Jia,
Quan Liu,
Xiao-Fei Wang,
Zhan-Lin Li,
Hui-Ming Hua

Affiliations

Ping Hu: Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of China
Da-Hong Li: Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of China
Cui-Cui Jia: Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of China
Quan Liu: Department of Pharmacology, Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100050, People’s Republic of China
Xiao-Fei Wang: Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of China
Zhan-Lin Li: Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of China; Corresponding author.
Hui-Ming Hua: Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of China; Corresponding author.

Journal volume & issue: Vol. 35
pp. 236 – 244

Abstract

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Vitex negundo L. var. heterophylla (Franch.) Rehd. is widely accepted as a functional and medicinal food in China because of the presence of bioactive components which improve the physical condition. In the present study, the bioactive constituents, antioxidant, α-glucosidase and DPP-IV inhibitory activities of V. negundo var. heterophylla were investigated. Two new coumarin glycosides, vitexnegheteroins I-J (1–2), and two new iridoid glycosides, vitexnegheteroins K-L (3–4), were isolated from the leaves and seeds of V. negundo var. heterophylla, together with twenty known compounds. Seven compounds presented stronger antioxidant activities than l-ascorbic acid in both DPPH and ABTS assays. Among them, isoorientin-6″-O-caffeate (22) also exhibited more potent α-glucosidase inhibitory activity than acarbose with an IC50 value of 0.24 ± 0.02 μM. These findings further revealed the bioactive components of this edible aromatic plant and disclosed the potency of it to be developed as new antioxidant and α-glucosidase inhibitory agents.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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