Eicosapentaenoic acid and docosahexaenoic acid suppress colonic tumorigenesis in obese mice

Yan Xu; Hui Zhang; Haitao Yang; Chundi Liu; Chunyan Song; Yinyin Cheng; Canxia He; Zuquan Zou; Dezheng Zhou; Guoqing Wu; Xiaohong Zhang

Journal of Functional Foods (May 2024)

Eicosapentaenoic acid and docosahexaenoic acid suppress colonic tumorigenesis in obese mice

Yan Xu,
Hui Zhang,
Haitao Yang,
Chundi Liu,
Chunyan Song,
Yinyin Cheng,
Canxia He,
Zuquan Zou,
Dezheng Zhou,
Guoqing Wu,
Xiaohong Zhang

Affiliations

Yan Xu: The Affiliated Hospital of Medical School, Ningbo University, Institute of Digestive Disease of Ningbo University, Ningbo, Zhejiang 315020, China; Shaoxing Center for Disease Control and Prevention, Shaoxing, Zhejiang 312071, China
Hui Zhang: Department of Public Health, School of Medicine, Ningbo University, Zhejiang Key Laboratory of Pathophysiology, Ningbo, Zhejiang 315211, China
Haitao Yang: Department of Pathology, Mingzhou Hospital of Zhejiang University, Ningbo, Zhejiang 315040, China
Chundi Liu: The Affiliated Stomatologic Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China
Chunyan Song: Department of Public Health, School of Medicine, Ningbo University, Zhejiang Key Laboratory of Pathophysiology, Ningbo, Zhejiang 315211, China
Yinyin Cheng: Department of Public Health, School of Medicine, Ningbo University, Zhejiang Key Laboratory of Pathophysiology, Ningbo, Zhejiang 315211, China
Canxia He: The Affiliated Hospital of Medical School, Ningbo University, Institute of Digestive Disease of Ningbo University, Ningbo, Zhejiang 315020, China; Department of Public Health, School of Medicine, Ningbo University, Zhejiang Key Laboratory of Pathophysiology, Ningbo, Zhejiang 315211, China
Zuquan Zou: Beilun District Center for Disease Control and Prevention, Ningbo, Zhejiang 315800, China
Dezheng Zhou: Department of Public Health, School of Medicine, Ningbo University, Zhejiang Key Laboratory of Pathophysiology, Ningbo, Zhejiang 315211, China; Corresponding authors at: Department of Public Health, School of Medicine, Ningbo University, Zhejiang Key Laboratory of Pathophysiology, Ningbo, Zhejiang 315211, China.
Guoqing Wu: The Affiliated Hospital of Medical School, Ningbo University, Institute of Digestive Disease of Ningbo University, Ningbo, Zhejiang 315020, China; Department of Public Health, School of Medicine, Ningbo University, Zhejiang Key Laboratory of Pathophysiology, Ningbo, Zhejiang 315211, China; Corresponding authors at: Department of Public Health, School of Medicine, Ningbo University, Zhejiang Key Laboratory of Pathophysiology, Ningbo, Zhejiang 315211, China.
Xiaohong Zhang: The Affiliated Hospital of Medical School, Ningbo University, Institute of Digestive Disease of Ningbo University, Ningbo, Zhejiang 315020, China; Department of Public Health, School of Medicine, Ningbo University, Zhejiang Key Laboratory of Pathophysiology, Ningbo, Zhejiang 315211, China; Corresponding authors at: Department of Public Health, School of Medicine, Ningbo University, Zhejiang Key Laboratory of Pathophysiology, Ningbo, Zhejiang 315211, China.

Journal volume & issue: Vol. 116
p. 106164

Abstract

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Chronic inflammation is a hallmark of obesity and is recognized as a cancer risk. While EPA and DHA combat inflammation associated with obesity, their effects on obesity-linked intestinal tumors requires further study. This study used the azoxymethane/dextran sulfate sodium (AOM/DSS) model in mice made obese by a high-fat diet to assess the effects of EPA and DHA on tumorigenesis. The results showed that obesity aggravates colon tumor development in mice, yet both EPA and DHA significantly suppressed tumor formation in the obese murine colon. EPA and DHA altered the intestinal epithelium's fatty acid profile, enhancing its anti-inflammatory properties. Both treatments led to a decrease in the pro-inflammatory Desulfovibrio, while EPA specifically increased probiotic Parasutterella and decreased mucus- destroying Bacteroides. In conclusion, EPA and DHA have inhibitory effects on colon tumor formation in obese mice, primarily by modulating the gut flora and inhibiting inflammation in the colon.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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Abstract

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