Ameliorative effect of dieckol-enriched extraction from Laminaria japonica on hepatic steatosis induced by a high-fat diet via β-oxidation pathway in ICR mice

Abstract

An increasing number of studies indicate that dietary polyphenols are beneficial to non-alcoholic fatty liver (NAFL) disease. However, the published reports about marine polyphenols are still limited. In this work, the ameliorative effect of polyphenols from Laminaria (L.) japonica on NAFL was investigated in vivo. According to the spectral analyses, dieckol was identified from L. japonica. After NAFL was induced by a high-fat diet, the ICR mice were administered dieckol-enriched extract (DEE) (50 mg/kg/day) for 4 weeks. Compared with the normal diet (ND) group, significant (P < 0.05) improvements in body weight gain, liver index, visceral fat index, plasma lipid profiles, and hepatic fat deposition were observed in ND + DEE group. Moreover, DEE supplementation selectively ameliorated levels of phosphorylated-AMP-activated protein kinase, carnitine palmitoyltransferase-1, and peroxisome proliferator-activated receptor-α in liver. Therefore, polyphenols from L. japonica might have potential ameliorative effect on hepatic steatosis via stimulating hepatic fatty acid β-oxidation.

Keywords

• Polyphenols
• Laminaria japonica
• Non-alcoholic fatty liver
• AMPK
• CPT-1
• PPAR-α