npj Vaccines (Oct 2021)
INO-4800 DNA vaccine induces neutralizing antibodies and T cell activity against global SARS-CoV-2 variants
- Viviane M. Andrade,
- Aaron Christensen-Quick,
- Joseph Agnes,
- Jared Tur,
- Charles Reed,
- Richa Kalia,
- Idania Marrero,
- Dustin Elwood,
- Katherine Schultheis,
- Mansi Purwar,
- Emma Reuschel,
- Trevor McMullan,
- Patrick Pezzoli,
- Kim Kraynyak,
- Albert Sylvester,
- Mammen P. Mammen,
- Pablo Tebas,
- J. Joseph Kim,
- David B. Weiner,
- Trevor R. F. Smith,
- Stephanie J. Ramos,
- Laurent M. Humeau,
- Jean D. Boyer,
- Kate E. Broderick
Affiliations
- Viviane M. Andrade
- Inovio Pharmaceuticals
- Aaron Christensen-Quick
- Inovio Pharmaceuticals
- Joseph Agnes
- Inovio Pharmaceuticals
- Jared Tur
- Inovio Pharmaceuticals
- Charles Reed
- Inovio Pharmaceuticals
- Richa Kalia
- Inovio Pharmaceuticals
- Idania Marrero
- Inovio Pharmaceuticals
- Dustin Elwood
- Inovio Pharmaceuticals
- Katherine Schultheis
- Inovio Pharmaceuticals
- Mansi Purwar
- Vaccine and Immunotherapy Center, Wistar Institute
- Emma Reuschel
- Vaccine and Immunotherapy Center, Wistar Institute
- Trevor McMullan
- Inovio Pharmaceuticals
- Patrick Pezzoli
- Inovio Pharmaceuticals
- Kim Kraynyak
- Inovio Pharmaceuticals
- Albert Sylvester
- Inovio Pharmaceuticals
- Mammen P. Mammen
- Inovio Pharmaceuticals
- Pablo Tebas
- Hospital of the University of Pennsylvania
- J. Joseph Kim
- Inovio Pharmaceuticals
- David B. Weiner
- Vaccine and Immunotherapy Center, Wistar Institute
- Trevor R. F. Smith
- Inovio Pharmaceuticals
- Stephanie J. Ramos
- Inovio Pharmaceuticals
- Laurent M. Humeau
- Inovio Pharmaceuticals
- Jean D. Boyer
- Inovio Pharmaceuticals
- Kate E. Broderick
- Inovio Pharmaceuticals
- DOI
- https://doi.org/10.1038/s41541-021-00384-7
- Journal volume & issue
-
Vol. 6,
no. 1
pp. 1 – 4
Abstract
Abstract Global surveillance has identified emerging SARS-CoV-2 variants of concern (VOC) associated with broadened host specificity, pathogenicity, and immune evasion to vaccine-induced immunity. Here we compared humoral and cellular responses against SARS-CoV-2 VOC in subjects immunized with the DNA vaccine, INO-4800. INO-4800 vaccination induced neutralizing antibodies against all variants tested, with reduced levels detected against B.1.351. IFNγ T cell responses were fully maintained against all variants tested.
