A review on animal and plant proteins in regulating diabetic kidney disease: Mechanism of action and future perspectives

Abstract

Diabetic kidney disease is a metabolic condition that can increase the risk of death. Reasonable protein diets can reduce the risk of developing kidney disease, delay its progression, and other complications. This review explores the pathogenesis of diabetic kidney disease, analyses the potential of protein in regulating its development in terms of its sources, and further elucidates the possible mechanism of protein influence on diabetic kidney disease. Finally, we present the potential advantages of moderately limited plant-based protein diets in managing diabetic kidney disease, and propose the promising future of protein-based foods. In particular, inflammation and oxidative stress are closely associated with the development and progression of diabetic kidney disease. Proteins are regulators of renal function, and plant proteins are more effective and pronounced than animal proteins in reducing the rate of its progression. Additionally, the benefit-risk ratios seem to be greater for plant-based, less processed dietary patterns.

Keywords

• Diabetic kidney disease
• Pathogenesis
• Dietary interventions
• Animal Protein
• Plant protein