Holothuria leucospilota polysaccharides alleviate liver injury via AMPK and NF-κB signaling pathways in type 2 diabetic rats

Fuqiang Zhao; Kexue Zhu; Qiancheng Zhao; Qibing Liu; Jun Cao; Guanghua Xia; Zhongyuan Liu; Chuan Li

Journal of Functional Foods (Oct 2021)

Holothuria leucospilota polysaccharides alleviate liver injury via AMPK and NF-κB signaling pathways in type 2 diabetic rats

Fuqiang Zhao,
Kexue Zhu,
Qiancheng Zhao,
Qibing Liu,
Jun Cao,
Guanghua Xia,
Zhongyuan Liu,
Chuan Li

Affiliations

Fuqiang Zhao: Hainan Engineering Research Center of Aquatic Resources Efficient Utilization in the South China Sea, School of Food Science and Engineering, Hainan University, Haikou 570228, China
Kexue Zhu: Spice and Beverage Research Institute, Chinese Academy of Tropical Agricultural Sciences, Wanning, Hainan 571533, China
Qiancheng Zhao: College of Food Science and Engineering, Dalian Ocean University, Dalian 116023, China; Collaborative Innovation Center of Seafood Deep Processing, National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian 116034, China
Qibing Liu: School of Basic Medicine and Life Science, Hainan Medical University, Haikou 571199, China
Jun Cao: Hainan Engineering Research Center of Aquatic Resources Efficient Utilization in the South China Sea, School of Food Science and Engineering, Hainan University, Haikou 570228, China
Guanghua Xia: Hainan Engineering Research Center of Aquatic Resources Efficient Utilization in the South China Sea, School of Food Science and Engineering, Hainan University, Haikou 570228, China; Collaborative Innovation Center of Seafood Deep Processing, National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian 116034, China
Zhongyuan Liu: Hainan Engineering Research Center of Aquatic Resources Efficient Utilization in the South China Sea, School of Food Science and Engineering, Hainan University, Haikou 570228, China; Collaborative Innovation Center of Seafood Deep Processing, National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian 116034, China
Chuan Li: Hainan Engineering Research Center of Aquatic Resources Efficient Utilization in the South China Sea, School of Food Science and Engineering, Hainan University, Haikou 570228, China; Collaborative Innovation Center of Seafood Deep Processing, National Engineering Research Center of Seafood, Dalian Polytechnic University, Dalian 116034, China; Corresponding author at: School of Food Science and Engineering, Hainan University, Haikou 570228, China.

Journal volume & issue: Vol. 85
p. 104657

Abstract

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The study evaluated the beneficial effects of orally administered Holothuria leucospilota polysaccharides (HLP) on liver injury in diabetic rats. The results showed that HLP regulated liver glycogen, glycosylated serum protein, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels. Simultaneously, HLP significantly reduced lipid accumulation in livers of diabetic rats (P < 0.05). In addition, HLP exerted anti-oxidant and anti-inflammatory activities, together with repaired histological impairment of liver in diabetes. Moreover, HLP downregulated the mRNA and protein expression of inhibitors of nuclear factor κB kinase β (IKKβ), nuclear factor κB P65 (NF-κB P65) and glycogen synthase kinase 3β (GSK3β), while upregulated the expression of nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1) and AMP-activated protein kinase α (AMPKα) in the liver. These findings suggested that HLP improved liver injury via AMPK and NF-κB related signaling pathways in type 2 diabetic rats.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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