Anti-allergic effect of strawberry extract

Akira Iwamoto; Aiko Inoue; Yuichi Inoue; Koji Yamada; Hirofumi Tachibana; Hiroharu Kawahara

Journal of Functional Foods (Oct 2013)

Anti-allergic effect of strawberry extract

Akira Iwamoto,
Aiko Inoue,
Yuichi Inoue,
Koji Yamada,
Hirofumi Tachibana,
Hiroharu Kawahara

Affiliations

Akira Iwamoto: Division of Applied Biological Chemistry, Department of Bioscience and Biochemistry, Faculty of Agriculture, Kyushu University, Fukuoka 812-8581, Japan
Aiko Inoue: Department of Materials Science and Chemical Engineering, Kitakyushu National College of Technology, 5-20-1 Shii, Kokuraminami-ku, Kitakyushu-shi, Fukuoka, 802-0985, Japan
Yuichi Inoue: Department of Materials Science and Chemical Engineering, Kitakyushu National College of Technology, 5-20-1 Shii, Kokuraminami-ku, Kitakyushu-shi, Fukuoka, 802-0985, Japan; Corresponding author. Tel./fax: +81 93 964 7243.
Koji Yamada: Division of Applied Biological Chemistry, Department of Bioscience and Biochemistry, Faculty of Agriculture, Kyushu University, Fukuoka 812-8581, Japan
Hirofumi Tachibana: Division of Applied Biological Chemistry, Department of Bioscience and Biochemistry, Faculty of Agriculture, Kyushu University, Fukuoka 812-8581, Japan
Hiroharu Kawahara: Department of Materials Science and Chemical Engineering, Kitakyushu National College of Technology, 5-20-1 Shii, Kokuraminami-ku, Kitakyushu-shi, Fukuoka, 802-0985, Japan

Journal volume & issue: Vol. 5, no. 4
pp. 1947 – 1955

Abstract

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We examined the anti-allergic effect of strawberry extract on human peripheral blood mononuclear cells (PBMCs) and atopic dermatitis model mice NC/NgaTndCrlj. The addition of strawberry extract suppressed total IgE production in the cedar pollen antigen Cry j 1-stimulated PBMCs. Flow cytometric analysis showed that strawberry extract decreased the rate of CD3+CD4+ helper T cells by 17.3% and increased the rate of CD3+CD8+ cytotoxic T cells by 19.7% in PBMCs. Moreover, the extract inhibited the expression level of GATA3 that is the master regulator of type 2 helper T cells (Th2) in human primary pan T cells isolated from PBMCs. Oral administration of strawberry extract lowered dermatitis scores and serum IgE levels in mice. In addition, it also decreased the GATA3 expression level in mouse blood cells. These results revealed that strawberry extract suppressed the severity of atopic dermatitis through the down-regulation of serum IgE by inhibition of Th2 differentiation.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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