Metabolomics and gene expression levels reveal the positive effects of teaseed oil on lifespan and aging process in Caenorhabditis elegans

Yanan Wang; Jiachen Shi; Kun Liu; Yu Wang; Yongjiang Xu; Yuanfa Liu

Food Science and Human Wellness (Jul 2023)

Metabolomics and gene expression levels reveal the positive effects of teaseed oil on lifespan and aging process in Caenorhabditis elegans

Yanan Wang,
Jiachen Shi,
Kun Liu,
Yu Wang,
Yongjiang Xu,
Yuanfa Liu

Affiliations

Yanan Wang: State Key Laboratory of Food Science and Technology, National Engineering Research Center for Functional Food, National Engineering Laboratory for Cereal Fermentation Technology, Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China
Jiachen Shi: State Key Laboratory of Food Science and Technology, National Engineering Research Center for Functional Food, National Engineering Laboratory for Cereal Fermentation Technology, Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China
Kun Liu: State Key Laboratory of Food Science and Technology, National Engineering Research Center for Functional Food, National Engineering Laboratory for Cereal Fermentation Technology, Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China
Yu Wang: State Key Laboratory of Food Science and Technology, National Engineering Research Center for Functional Food, National Engineering Laboratory for Cereal Fermentation Technology, Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China
Yongjiang Xu: State Key Laboratory of Food Science and Technology, National Engineering Research Center for Functional Food, National Engineering Laboratory for Cereal Fermentation Technology, Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China
Yuanfa Liu: Corresponding author at: School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.; State Key Laboratory of Food Science and Technology, National Engineering Research Center for Functional Food, National Engineering Laboratory for Cereal Fermentation Technology, Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China

Journal volume & issue: Vol. 12, no. 4
pp. 1391 – 1401

Abstract

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As an irreplaceable dietary constituent, lipids play a vital important role in health, but their effects on aging process and longevity are still not well known yet. In this paper, the metabolic profiling and gene expression levels of Caenorhabditis elegans were investigated to explore the effects of different edible oils on senescence and lifespan. The results showed that teaseed oil (TO) could prolong the life expectancy and slow down the aging process of C. elegans. Compared to the control group, the intake of lard oil (LO) and TO increased the expression levels of genes related to inhibition of protein aggregation (akt-1, daf-16, hsf-1, hsp-16.2) and lipid metabolism (daf-7, daf-1, mdt-15, lipl-4, fat-5, fat-6, fat-7), with a more significant alteration in TO group. Metabolomics revealed that palm oil can upregulated plenty of fatty acids (palmitic acid, stearic acid, tetracosanoic acid), together with some amino acids (tryptophan, L-aspartate, L-valine) and carbohydrate (D-glucose), while the trend was opposite in TO group. Besides, moderate-to-strong correlations were found between differential metabolites and changed genes. In general, this paper claimed that TO could prolong lifespan and slow down aging process via regulating the lipids, amino acids and carbohydrates metabolism.

Published in Food Science and Human Wellness

ISSN: 2213-4530 (Online)
Publisher: Tsinghua University Press
Country of publisher: China
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.sciopen.com/journal/2097-0765

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