Nature Communications (2018-02-01)

A transcriptomic atlas of aged human microglia

  • Marta Olah,
  • Ellis Patrick,
  • Alexandra-Chloe Villani,
  • Jishu Xu,
  • Charles C. White,
  • Katie J. Ryan,
  • Paul Piehowski,
  • Alifiya Kapasi,
  • Parham Nejad,
  • Maria Cimpean,
  • Sarah Connor,
  • Christina J. Yung,
  • Michael Frangieh,
  • Allison McHenry,
  • Wassim Elyaman,
  • Vlad Petyuk,
  • Julie A. Schneider,
  • David A. Bennett,
  • Philip L. De Jager,
  • Elizabeth M. Bradshaw

DOI
https://doi.org/10.1038/s41467-018-02926-5
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 8

Abstract

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Aging is associated with various changes in the brain, including transcription alteration. Here, Bradshaw and colleagues describe the transcriptome of aged human cortical microglia, and show age-related gene expression as related to neurodegeneration.