Applications of new functions for inducing host defense peptides and synergy sterilization of medium chain fatty acids in substituting in-feed antibiotics

Zhongxin Zhou; Jie Huang; Haihong Hao; Hongkui Wei; Yuanfei Zhou; Jian Peng

Journal of Functional Foods (Jan 2019)

Applications of new functions for inducing host defense peptides and synergy sterilization of medium chain fatty acids in substituting in-feed antibiotics

Zhongxin Zhou,
Jie Huang,
Haihong Hao,
Hongkui Wei,
Yuanfei Zhou,
Jian Peng

Affiliations

Zhongxin Zhou: Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Department of Animal Nutrition and Feed Science, College of Animal Sciences & Technology, Huazhong Agriculture University, 1 Shizishan Street, Wuhan 430070, China; The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agriculture University, 1 Shizishan Street, Wuhan 430070, China; Corresponding authors at: Department of Animal Nutrition and Feed Science, College of Animal Sciences & Technology, Huazhong Agriculture University, 1 Shizishan Street, Wuhan 430070, China.
Jie Huang: Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Department of Animal Nutrition and Feed Science, College of Animal Sciences & Technology, Huazhong Agriculture University, 1 Shizishan Street, Wuhan 430070, China; The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agriculture University, 1 Shizishan Street, Wuhan 430070, China
Haihong Hao: National Reference Laboratory of Veterinary Drug Residues (HZAU), Huazhong Agriculture University, 1 Shizishan Street, Wuhan 430070, China
Hongkui Wei: Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Department of Animal Nutrition and Feed Science, College of Animal Sciences & Technology, Huazhong Agriculture University, 1 Shizishan Street, Wuhan 430070, China; The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agriculture University, 1 Shizishan Street, Wuhan 430070, China
Yuanfei Zhou: Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Department of Animal Nutrition and Feed Science, College of Animal Sciences & Technology, Huazhong Agriculture University, 1 Shizishan Street, Wuhan 430070, China; The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agriculture University, 1 Shizishan Street, Wuhan 430070, China
Jian Peng: Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Department of Animal Nutrition and Feed Science, College of Animal Sciences & Technology, Huazhong Agriculture University, 1 Shizishan Street, Wuhan 430070, China; The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agriculture University, 1 Shizishan Street, Wuhan 430070, China; Corresponding authors at: Department of Animal Nutrition and Feed Science, College of Animal Sciences & Technology, Huazhong Agriculture University, 1 Shizishan Street, Wuhan 430070, China.

Journal volume & issue: Vol. 52
pp. 348 – 359

Abstract

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Developing alternatives to classic antibiotic growth promoters (AGPs) in feed industry has been being urgently called but an individual alternative is unlikely to embody all functions of classic antibiotics. One potential solution is to select multiple products which work synergistically and a comprehensive solution. This review mainly discuss recent advances in medium-chain fatty acids’ (MCFAs) roles as an important component of the mammalian innate immune defense system, new functions for inducing host defense peptides and synergy sterilizations with edible essential oils or edible organic acids, and these multifaceted functions’ application potential to solve their technological challenges in substituting in-feed antibiotics such as unpleasant odor, low solubility, poor chemical stability and volatile nature. The review highlights that MCFAs are originally an important component of innate immune defense system in mammalian breast milk, skin and mucosa, and also induce host defense peptide expression in human, pig, chicken, rabbit and mice, which are beneficial supplement to their previously found in vitro antimicrobial functions. It is concluded that using encapsulated MCFAs combinations with edible essential oils or organic acids would be one preferred solution to overcome their technological challenges in substituting in-feed antibiotics such as unpleasant odor, low solubility, poor chemical stability and volatile nature, and also have the relative difficulty with which bacteria develop resistance. However, the basic data related to combinations of various alternatives and the underlying mechanisms remain lacking.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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