Ingestion of isomalto-oligosaccharides stimulates insulin and incretin hormone secretion in healthy adults

Fatheema B. Subhan; Zohre Hashemi; M. Carolina Archundia Herrera; Kristen Turner; Sarah Windeler; Michael G. Gänzle; Catherine B. Chan

Journal of Functional Foods (Feb 2020)

Ingestion of isomalto-oligosaccharides stimulates insulin and incretin hormone secretion in healthy adults

Fatheema B. Subhan,
Zohre Hashemi,
M. Carolina Archundia Herrera,
Kristen Turner,
Sarah Windeler,
Michael G. Gänzle,
Catherine B. Chan

Affiliations

Fatheema B. Subhan: Dept. of Agricultural, Food and Nutritional Sciences, University of Alberta, Edmonton, Alberta T6G 2E1, Canada
Zohre Hashemi: Dept. of Agricultural, Food and Nutritional Sciences, University of Alberta, Edmonton, Alberta T6G 2E1, Canada
M. Carolina Archundia Herrera: Dept. of Agricultural, Food and Nutritional Sciences, University of Alberta, Edmonton, Alberta T6G 2E1, Canada
Kristen Turner: Dept. of Agricultural, Food and Nutritional Sciences, University of Alberta, Edmonton, Alberta T6G 2E1, Canada
Sarah Windeler: Dept. of Agricultural, Food and Nutritional Sciences, University of Alberta, Edmonton, Alberta T6G 2E1, Canada
Michael G. Gänzle: Dept. of Agricultural, Food and Nutritional Sciences, University of Alberta, Edmonton, Alberta T6G 2E1, Canada; Hubei University of Technology, College of Bioengineering and Food Science, Wuhan, Hubei, PR China
Catherine B. Chan: Dept. of Agricultural, Food and Nutritional Sciences, University of Alberta, Edmonton, Alberta T6G 2E1, Canada; Dept. of Physiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta T6G 2H7, Canada; Corresponding author at: 6-126B Li Ka Shing Centre for Health Research Innovation, University of Alberta, Edmonton, Alberta T6G 2E1, Canada.

Journal volume & issue: Vol. 65
p. 103730

Abstract

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The postprandial blood glucose and hormonal responses to isomalto-oligosaccharides (IMO) are unclear. The objective of this study was to compare postprandial glucose, insulin and incretin responses of IMO with dextrose in healthy adults. In trial 1, blood glucose responses to IMO, isomaltose, dextran and maltodextrin were compared with dextrose in n = 12 participants. In trial 2, serial glucose and hormone measurements over 2 h were measured in n = 10 participants. The glycemic effect of IMO was calculated using the Glycemic Glucose Equivalents (GGE) and Relative Glycemic Index (RGI). IMO exhibited a hyperglycemic effect compared to dextrose as indicated by a GGE of 1.35 g and an RGI of 27.0 g. The responses to IMO of both active GLP-1 and GIP were similar to that of dextrose. The paradoxical hyperglycemic response despite robust insulin and incretin secretion requires further investigation.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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