Exploring anti-inflammatory non-essential oil metabolites in Mentha canadensis: Insights into neutrophil extracellular trap inhibition for functional health promotion

Huong-Giang Le; Yun-Shiuan Chen; Tzu-Peng Cheng; Yung-Fong Tsai; Po-Jen Chen; Wen-Chi Cheng; Mohamed El-Shazly; Yu-Chia Chang; Tsong-Long Hwang; Kuei-Hung Lai

Journal of Functional Foods (Jun 2024)

Exploring anti-inflammatory non-essential oil metabolites in Mentha canadensis: Insights into neutrophil extracellular trap inhibition for functional health promotion

Huong-Giang Le,
Yun-Shiuan Chen,
Tzu-Peng Cheng,
Yung-Fong Tsai,
Po-Jen Chen,
Wen-Chi Cheng,
Mohamed El-Shazly,
Yu-Chia Chang,
Tsong-Long Hwang,
Kuei-Hung Lai

Affiliations

Huong-Giang Le: Clinical Drug Development of Herbal Medicine, College of Pharmacy, Taipei Medical University, Taipei 110301, Taiwan
Yun-Shiuan Chen: Clinical Drug Development of Herbal Medicine, College of Pharmacy, Taipei Medical University, Taipei 110301, Taiwan; Graduate Institute of Pharmacognosy, College of Pharmacy, Taipei Medical University, Taipei 110301, Taiwan
Tzu-Peng Cheng: Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333323, Taiwan
Yung-Fong Tsai: Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333323, Taiwan; Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 333423, Taiwan; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 333323, Taiwan
Po-Jen Chen: Department of Medical Research, E-Da Hospital, I-Shou University, Kaohsiung 824005, Taiwan; Graduate Institute of Medicine, I-Shou University, Kaohsiung 824410, Taiwan
Wen-Chi Cheng: Graduate Institute of Pharmacognosy, College of Pharmacy, Taipei Medical University, Taipei 110301, Taiwan
Mohamed El-Shazly: Department of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Organization of African Unity Street, Abassia, Cairo 11566, Egypt
Yu-Chia Chang: Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333324, Taiwan; Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333324, Taiwan
Tsong-Long Hwang: Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333323, Taiwan; Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333324, Taiwan; Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333324, Taiwan; Department of Chemical Engineering, Ming Chi University of Technology, New Taipei City 243303, Taiwan
Kuei-Hung Lai: Clinical Drug Development of Herbal Medicine, College of Pharmacy, Taipei Medical University, Taipei 110301, Taiwan; Graduate Institute of Pharmacognosy, College of Pharmacy, Taipei Medical University, Taipei 110301, Taiwan; Traditional Herbal Medicine Research Center, Taipei Medical University Hospital, Taipei 110301, Taiwan; Corresponding author at: Clinical Drug Development of Herbal Medicine, College of Pharmacy, Taipei Medical University, Taipei 110301, Taiwan.

Journal volume & issue: Vol. 117
p. 106233

Abstract

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Mentha canadensis, commonly known as Canadian mint, has been utilized in herbal medicine for its menthol content, addressing digestive and respiratory issues. It also serves as a popular culinary herb, adding a refreshing minty flavor to dishes and beverages. However, research on its non-essential oils and their anti-inflammatory potential is lacking. This study utilized multi-informative molecular networking to comprehensively profile the non-essential oils of M. canadensis. Cinnamic acid derivatives were identified as potent anti-inflammatory agents, with high activity ratings. By analyzing the Molecular Networking (MN) database, fourteen metabolites were identified. Compounds within the bioactive MN clusters demonstrate significant inhibition of reactive oxygen species generation, playing a crucial role in the management of oxidative stress. These compounds also effectively suppressed the formation of neutrophil extracellular traps. In conclusion, salvianolic acid B (IC50: 0.08 μM) was promoted as the chemical marker of M. canadensis for its potential anti-inflammatory effect. This study pioneers the identification of anti-inflammatory metabolites in M. canadensis' non-essential oils, offering insights into its therapeutic properties and potential for health-centric culinary applications.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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