Scientific and Pharmaceutical Aspects of <i>Christensenella minuta</i>, a Promising Next-Generation Probiotic
Ágota Pető,
Dóra Kósa,
Zoltán Szilvássy,
Pálma Fehér,
Zoltán Ujhelyi,
Gabriella Kovács,
István Német,
István Pócsi,
Ildikó Bácskay
Affiliations
Ágota Pető
Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Nagyerdei Körút 98, 4032 Debrecen, Hungary
Dóra Kósa
Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Nagyerdei Körút 98, 4032 Debrecen, Hungary
Zoltán Szilvássy
Department of Pharmacology and Pharmacotherapy, Faculty of General Medicine, University of Debrecen, Nagyerdei Körút 98, 4032 Debrecen, Hungary
Pálma Fehér
Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Nagyerdei Körút 98, 4032 Debrecen, Hungary
Zoltán Ujhelyi
Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Nagyerdei Körút 98, 4032 Debrecen, Hungary
Gabriella Kovács
Fluart Innovative Vaccines Ltd., Fő út 7, 2097 Pilisborosjenő, Hungary
István Német
Fluart Innovative Vaccines Ltd., Fő út 7, 2097 Pilisborosjenő, Hungary
István Pócsi
Department of Molecular Biotechnology and Microbiology, Institute of Biotechnology, Faculty of Science and Technology, University of Debrecen, Egyetem tér 1, 4032 Debrecen, Hungary
Ildikó Bácskay
Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Nagyerdei Körút 98, 4032 Debrecen, Hungary
Christensenella minuta (C. minuta), a member of a recently described bacterial family, is one of the most heritable next-generation probiotics. Many observational studies confirmed that the relative abundance of C. minuta is associated with lean body types with a low host body mass index (BMI), and is also influenced by age, diet, and genetics. By utilizing its benefits, it could be suited to many therapies, including human and animal health as well. However, a reliable method for culturing the strain must also be developed to enable the therapeutic administration of the microbe. Sludge microfiltration could be a promising solution for large scale-up cultivation. In this review, different processing methods are also described from pharmaceutical aspects.
