Incorporation of new aniline fatty derivatives in to lymphatic chylomicrons

Abstract

Some compounds, other than fatty anilides, which had been isolated from oil samples involved in the "toxic syndrome", has been obtained by chemical synthesis. These substances are 3-phenylamine-1,2 propanediol and its fatty acyl mono- and diesters derivatives. These products have been orally administered to rats whose lymphatic canal had previously been cannulated. Samples of lymph were taken periodically. After isolation of chylomicrons from the lymphatic samples and analysis of its lipids by thin layer chromatography, we were able to detect the presence of the above mentioned compounds as well as a metabolic product of them. These results suggest that these products are incorporated into the blood via lymphatic absortion.

Keywords

• aniline (derivatives of)
• chylomicrons
• denatured oil
• lymph
• 2-phenylamine-1
• 2-propanediol
• 3-phenylamine-1
• 2- propanediol (esters of)