JBB attenuates acute and chronic alcoholic liver injury by regulating the NFκB, KEAP1, and HIF1 pathways

Abstract

Alcoholic liver disease (ALD) is a liver injury caused by chronic or binge alcohol consumption. Jiubanban (JBB) is a 10-edible-herb- formula. The current study investigated the protective effects and mechanisms of JBB against chronic alcoholic liver injury. The results showed that JBB significantly alleviated chronic alcoholic liver injury caused by chronic-binge alcohol consumption. JBB accelerated ethanol metabolism and had a protective effect on both acute and chronic alcoholic liver injury. By modulating the NFκB, KEAP1, and HIF1 pathways, JBB was shown to reduce the production of cytokines (IL-6 and TNFα), enhanced the activity of anti-oxidative enzymes (SOD and GSH-px), reduced associated products (ROS and MDA), reversing inflammation, oxidative stress, and apoptosis. The study findings suggest that this functional herbal food combination may be a risk-free therapeutic strategy for treating ALD.

Keywords

• Alcoholic liver injury
• Oxidative stress
• Inflammatory
• Hepatoprotective
• Edible herb