Lipid nanoparticles based on omega-3 fatty acids as effective carriers for lutein delivery. Preparation and in vitro characterization studies

Ioana Lacatusu; Elena Mitrea; Nicoleta Badea; Raluca Stan; Ovidiu Oprea; Aurelia Meghea

Journal of Functional Foods (Jul 2013)

Lipid nanoparticles based on omega-3 fatty acids as effective carriers for lutein delivery. Preparation and in vitro characterization studies

Ioana Lacatusu,
Elena Mitrea,
Nicoleta Badea,
Raluca Stan,
Ovidiu Oprea,
Aurelia Meghea

Affiliations

Ioana Lacatusu: Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Polizu Street No. 1, 011061 Bucharest, Romania; Petroleum-Gas University of Ploiesti, Bucuresti Street No. 39, 100680 Ploiesti, Romania
Elena Mitrea: Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Polizu Street No. 1, 011061 Bucharest, Romania; Biofarm S.A., Logofat Tautu Street No. 99, 31212 Bucharest, Romania
Nicoleta Badea: Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Polizu Street No. 1, 011061 Bucharest, Romania; Corresponding author. Tel./fax: +40 0213154193.
Raluca Stan: Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Polizu Street No. 1, 011061 Bucharest, Romania
Ovidiu Oprea: Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Polizu Street No. 1, 011061 Bucharest, Romania
Aurelia Meghea: Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Polizu Street No. 1, 011061 Bucharest, Romania; Corresponding author. Tel./fax: +40 0213154193.

Journal volume & issue: Vol. 5, no. 3
pp. 1260 – 1269

Abstract

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This study aimed at exploring the behavior of fish oil enriched with ω-3 fatty acids in order to obtain stable lipid nanocarriers (NLCs) with improved characteristics as effective delivery systems for lutein. The particle size of optimized lutein-NLCs was below 200 nm. The less ordered arrangement of lipid core revealed by scanning calorimetry and the high entrapment efficiency of 88.5% clearly indicated the appropriate role of fish oil in obtaining effective lipid nanocarriers. The evaluation of in vitro antioxidant activity has demonstrated a significant blocking effect of NLCs, scavenging up to 98% oxygen free radicals. The in vitro release profile has shown that NLCs are able to ensure a better, in vitro sustained release of lutein as compared to conventional nanoemulsions.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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