Alpha-terpinyl acetate: A natural monoterpenoid from Elettaria cardamomum as multi-target directed ligand in Alzheimer’s disease

Abstract

Alzheimer's disease (AD), is a multifactorial neurodegenerative disorder characterized by memory loss and cognitive deficit. Various drug targets implicated in AD are β-amyloid (Aβ) peptides, cholinesterase enzymes, and free radicals. Plants derived phytoconstituents provides a vast pool of diverse compounds as a source of novel drugs. In view of this, the Elettaria cardamomum L. Maton. extract and its active phytoconstituents alpha-terpinyl acetate were used to study the disease-modifying effects in AD. The present study successfully demonstrated for the first time the therapeutic potential of alpha-terpinyl acetate as it binds to multiple drug targets, resulting in inhibition of acetylcholinesterase (AChE) enzyme, butyrylcholinesterase (BuChE) enzyme, reduced Aβ induced neurotoxicity, reduced hydrogen peroxide induced oxidative stress, antioxidant capacity, and anti-amyloidogenic property. In conclusion, alpha-terpinyl acetate can be used as a suitable lead to develop a molecule that might have multi-targeted directed ligand (MTDL) potential and disease amelioration effects in AD.

Keywords

• Alzheimer's disease
• Alpha-terpinyl acetate
• Anti-cholinesterase
• Elettaria cardamomum L. Maton.
• Multi-targeted directed ligand (MTDL)
• Neuroprotection