Cyanidin-3-glucoside protects liver from oxidative damage through AMPK/Nrf2 mediated signaling pathway in vivo and in vitro

Liang Yu; Sun-dong Zhang; Xue-lian Zhao; Hai-yan Ni; Xin-rui Song; Wei Wang; Li-ping Yao; Xiu-hua Zhao; Yu-jie Fu

Journal of Functional Foods (Oct 2020)

Cyanidin-3-glucoside protects liver from oxidative damage through AMPK/Nrf2 mediated signaling pathway in vivo and in vitro

Liang Yu,
Sun-dong Zhang,
Xue-lian Zhao,
Hai-yan Ni,
Xin-rui Song,
Wei Wang,
Li-ping Yao,
Xiu-hua Zhao,
Yu-jie Fu

Affiliations

Liang Yu: College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, 518055, PR China
Sun-dong Zhang: College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, 518055, PR China
Xue-lian Zhao: College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, 518055, PR China
Hai-yan Ni: College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, 518055, PR China
Xin-rui Song: College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, 518055, PR China
Wei Wang: College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, 518055, PR China
Li-ping Yao: College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, 518055, PR China
Xiu-hua Zhao: College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, 518055, PR China
Yu-jie Fu: College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, 518055, PR China; Heilongjiang Touyan Innovation Team Program(Tree Genetics and Breeding Innovation Team), Harbin 150001, PR China; College of Forestry, Beijing Forestry University, Beijing 100083, PR China; Corresponding author at: College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, 518055, PR China; Heilongjiang Touyan Innovation Team Program(Tree Genetics and Breeding Innovation Team), Harbin 150001, PR China; College of Forestry, Beijing Forestry University, Beijing 100083, China.

Journal volume & issue: Vol. 73
p. 104148

Abstract

Read online

Cyanidin-3-glucoside (C3G) has been demonstrated to have hepatoprotective effect for oxidative stress-related liver damage due to its antioxidant activity. However, the antioxidant mechanisms of C3G are not fully understood. In this study, the hepatoprotective effect of C3G was evaluated and the underlying molecular mechanisms were investigated in vivo and in vitro. C3G attenuated H2O2 induced cell apoptosis through ROS scavenging and enhancing the antioxidant defence system in vitro. The AMPK/Nrf-2 signal pathway is involved in the mechanism of protective effect of C3G. In addition, the hepatoprotective effect of C3G has been demonstrated in vivo. C3G alleviated CCl4-induced liver damage in mice through elevating antioxidant enzymes activities and upregulating Nrf2-antioxidant pathway. The findings suggest that C3G exhibits hepatoprotective effect. The results indicated that C3G exhibits hepatoprotective effect and could be used as a potential alternative for the liver against oxidative damage.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

About the journal

Abstract

Keywords