Anxiolytic activities of Matcha tea powder, extracts, and fractions in mice: Contribution of dopamine D1 receptor- and serotonin 5-HT1A receptor-mediated mechanisms

Yuki Kurauchi; Hari Prasad Devkota; Kengo Hori; Yuiko Nishihara; Akinori Hisatsune; Takahiro Seki; Hiroshi Katsuki

Journal of Functional Foods (Aug 2019)

Anxiolytic activities of Matcha tea powder, extracts, and fractions in mice: Contribution of dopamine D1 receptor- and serotonin 5-HT1A receptor-mediated mechanisms

Yuki Kurauchi,
Hari Prasad Devkota,
Kengo Hori,
Yuiko Nishihara,
Akinori Hisatsune,
Takahiro Seki,
Hiroshi Katsuki

Affiliations

Yuki Kurauchi: Department of Chemico-Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan
Hari Prasad Devkota: Department of Medical Botany, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan; Priority Organization for Innovation and Excellence, Kumamoto University, Kumamoto 860-8555, Japan; Program for Leading Graduate Schools “HIGO (Health Life Science: Interdisciplinary and Glocal Oriented) Program”, Kumamoto University, Kumamoto 862-0973, Japan
Kengo Hori: Department of Medical Botany, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan
Yuiko Nishihara: Department of Chemico-Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan
Akinori Hisatsune: Priority Organization for Innovation and Excellence, Kumamoto University, Kumamoto 860-8555, Japan; Program for Leading Graduate Schools “HIGO (Health Life Science: Interdisciplinary and Glocal Oriented) Program”, Kumamoto University, Kumamoto 862-0973, Japan
Takahiro Seki: Department of Chemico-Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan
Hiroshi Katsuki: Department of Chemico-Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto 862-0973, Japan; Corresponding author at: Department of Chemico-Pharmacological Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan.

Journal volume & issue: Vol. 59
pp. 301 – 308

Abstract

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Matcha is thought to be beneficial for brain functions; however, only a few scientific studies have shown the effects of Matcha tea powder on psychiatric behavior. Here, we evaluated the anxiolytic activity of Matcha tea powder, and its hot water extract (CSW) and ethanol extract (CSE) in mice, using the elevated plus maze test. Oral administration of Matcha tea powder and CSE exerted anxiolytic effects. CSE was further fractionated into hexane soluble (CSEH), ethyl acetate soluble (CSEE) and water soluble (CSEW) fractions. Among the fractions, CSEE and CSEH exerted anxiolytic effects. Moreover, SCH23390, a dopamine D1 receptor blocker, and WAY100135, an antagonist of the serotonin (5-hydroxytryptamine: 5-HT) 1A receptor, prevented Matcha tea powder and CSEE from exerting their anxiolytic effects. These results suggest that Matcha tea powder exerts anxiolytic effect through the activation of the dopaminergic and serotonergic systems.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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