Regulates macrophage polarization via the lipophage-NLRP3 inflammasome to ameliorate atherosclerosis in ApoE-/- mice

Jing Luo; Ming Chen; Hongwu Ji; Jiayi Chen; Wenkui Song; Di Zhang; Weiming Su; Shucheng Liu; Julieth Joram Majura

Journal of Functional Foods (Jul 2024)

Regulates macrophage polarization via the lipophage-NLRP3 inflammasome to ameliorate atherosclerosis in ApoE-/- mice

Jing Luo,
Ming Chen,
Hongwu Ji,
Jiayi Chen,
Wenkui Song,
Di Zhang,
Weiming Su,
Shucheng Liu,
Julieth Joram Majura

Affiliations

Jing Luo: College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, PR China
Ming Chen: College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, PR China
Hongwu Ji: College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, PR China; Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Zhanjiang 524088, PR China; Guangdong Province Engineering Laboratory for Marine Biological Products, Zhanjiang 524088, PR China; Guangdong Provincial Engineering Technology Research Center of Seafood, Zhanjiang 524088, PR China; Guangdong Provincial Engineering Technology Research Center of Prefabricated Seafood Processing and Quality Control, Zhanjiang 524088; Corresponding author at: College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, PR China.
Jiayi Chen: College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, PR China
Wenkui Song: College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, PR China
Di Zhang: College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, PR China
Weiming Su: College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, PR China; Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Zhanjiang 524088, PR China
Shucheng Liu: College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, PR China; Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Zhanjiang 524088, PR China; Guangdong Province Engineering Laboratory for Marine Biological Products, Zhanjiang 524088, PR China; Guangdong Provincial Engineering Technology Research Center of Seafood, Zhanjiang 524088, PR China; Guangdong Provincial Engineering Technology Research Center of Prefabricated Seafood Processing and Quality Control, Zhanjiang 524088; Collaborative Innovation Center of Seafood Deep Processing, Dalian Polytechnic University, Dalian 116034, PR China
Julieth Joram Majura: College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, PR China

Journal volume & issue: Vol. 118
p. 106280

Abstract

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To explore the mechanism of carnosine in improving atherosclerosis, ApoE-/- mice fed a high-fat diet (HFD) were orally administered different doses of carnosine for 16 weeks. Carnosine intervention significantly reduced the arterial plaque area and expression levels of IL-6, TNF-α, and IL-1β mRNA and increased the expression levels of IL-10 mRNA. Carnosine intervention increased LC3B, Beclin-1, and Atg7 mRNA expression levels and reduced ASC, NLRP3, and Caspase-1 mRNA expression levels. Meanwhile, carnosine could increase Arg-1, CD163, and CD206 mRNA expression levels and decrease iNOS mRNA expression levels. These results suggested that carnosine might regulate macrophage polarization by inhibiting the NLRP3 inflammasome through autophagy to alleviate atherosclerosis, which revealed a novel idea for carnosine to suppress atherosclerosis and offered a scientific foundation for the production of carnosine-enriched dietary products.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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