Nutraceuticals: A source of benefaction for neuropathic pain and fibromyalgia

Abstract

Though both neuropathy and fibromyalgia are serious complications that cause widespread pain, distinguishing between the two in order to provide adequate care is difficult. Metabolic disorders, chemotherapy, and neurotoxic exposure are frequently reported with neuropathic pain, whereas inflammatory and musculoskeletal diseases are associated with fibromyalgia. In recent years, these pain syndromes have become a significant challenge for healthcare experts due to their complex etiology, limited drug availability, and effectiveness. Notably, pharmaceutical drugs (antidepressants, anticonvulsants) available today have adverse effects, including physical dependence and tolerance. Therefore, a plethora of nutraceuticals has drawn considerable attention from patients seeking relief from chronic pain conditions. Nonetheless, only a few preclinical and clinical studies have been conducted to establish the safety and efficacy of these supplements. The current review concentrates on the role of a variety of nutraceuticals in the treatment of neuropathic pain and fibromyalgia, as well as their potential mechanisms and clinical trials.

Keywords

• Fibromyalgia
• Neuropathic pain
• Neurotransmitters
• Nutraceuticals
• Spinal cord injury
• Spared nerve injury