Anthocyanins from purple corn ameliorated obesity in high fat diet-induced obese mice through activating hepatic AMPK

Hongyan Xu; Meihong Liu; Huimin Liu; Bailing Zhao; Mingzhu Zheng; Jingsheng Liu

Journal of Functional Foods (Sep 2021)

Anthocyanins from purple corn ameliorated obesity in high fat diet-induced obese mice through activating hepatic AMPK

Hongyan Xu,
Meihong Liu,
Huimin Liu,
Bailing Zhao,
Mingzhu Zheng,
Jingsheng Liu

Affiliations

Hongyan Xu: College of Food Science and Engineering, Jilin Agricultural University, Changchun, Jilin 130118, China; National Engineering Laboratory for Wheat and Corn Deep Processing, Jilin Agricultural University, Changchun, Jilin 130118, China; Department of Food Science and Engineering, College of Agriculture, Yanbian University, Yanji, Jilin 133000, China
Meihong Liu: College of Food Science and Engineering, Jilin Agricultural University, Changchun, Jilin 130118, China; National Engineering Laboratory for Wheat and Corn Deep Processing, Jilin Agricultural University, Changchun, Jilin 130118, China
Huimin Liu: College of Food Science and Engineering, Jilin Agricultural University, Changchun, Jilin 130118, China; National Engineering Laboratory for Wheat and Corn Deep Processing, Jilin Agricultural University, Changchun, Jilin 130118, China; Corresponding authors at: College of Food Science and Engineering, Jilin Agricultural University, 2888 Xincheng Street, Changchun 130118, China.
Bailing Zhao: College of Food Science and Engineering, Jilin Agricultural University, Changchun, Jilin 130118, China; National Engineering Laboratory for Wheat and Corn Deep Processing, Jilin Agricultural University, Changchun, Jilin 130118, China
Mingzhu Zheng: College of Food Science and Engineering, Jilin Agricultural University, Changchun, Jilin 130118, China; National Engineering Laboratory for Wheat and Corn Deep Processing, Jilin Agricultural University, Changchun, Jilin 130118, China
Jingsheng Liu: College of Food Science and Engineering, Jilin Agricultural University, Changchun, Jilin 130118, China; National Engineering Laboratory for Wheat and Corn Deep Processing, Jilin Agricultural University, Changchun, Jilin 130118, China; Corresponding authors at: College of Food Science and Engineering, Jilin Agricultural University, 2888 Xincheng Street, Changchun 130118, China.

Journal volume & issue: Vol. 84
p. 104582

Abstract

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Anthocyanins are the predominant bioactive compounds in purple corn. Various studies suggested that anthocyanins from purple corn (APM) not only provide color but also provide potential health-promoting properties. However, there is no research addressing the antiobesity effects of APM via hepatic AMP-activated protein kinase (AMPK) pathway. We find that APM administration (400 mg/kg) significantly decreased body weight gain, epididymal fat mass, total cholesterol and total triglyceride levels in HFD mice. Quantitative PCR analysis revealed that APM down-regulated the expression of PPARγ, C/EBPα and SREBP-1c, concurrently up-regulated the expression of PPARα, PGC1α, PRDM16, and FGF21. Besides, Western blot analysis confirmed that APM promoted hepatic AMPK activity, then blocked ACC activity, which was the key enzyme in lipid synthase. These findings suggested that APM-induced activation of hepatic AMPK leads to a decrease in fatty acid synthase and an increase in fatty acid oxidation. Therefore, we inferred that APM has the potential for obesity prevention.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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