Systems pharmacology uncovers the mechanisms of anti-asthma herbal medicine intervention (ASHMI) for the prevention of asthma

Wei Zhou; Ziyi Chen; Weiqing Li; Yonghua Wang; Xiumin Li; Haiqiong Yu; Peixin Ran; Zhigang Liu

Journal of Functional Foods (Jan 2019)

Systems pharmacology uncovers the mechanisms of anti-asthma herbal medicine intervention (ASHMI) for the prevention of asthma

Wei Zhou,
Ziyi Chen,
Weiqing Li,
Yonghua Wang,
Xiumin Li,
Haiqiong Yu,
Peixin Ran,
Zhigang Liu

Affiliations

Wei Zhou: Department of Allergy, The Third Affiliated Hospital of Shenzhen University, Shenzhen 518020, China; Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China
Ziyi Chen: Musculoskeletal Research Laboratory, Department of Orthopaedics & Traumatology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin 999077, Hong Kong Special Administrative Region
Weiqing Li: Department of Allergy, The Third Affiliated Hospital of Shenzhen University, Shenzhen 518020, China
Yonghua Wang: College of Life Sciences, Northwest University, Shaanxi 712100, China
Xiumin Li: Department of Allergy, The Third Affiliated Hospital of Shenzhen University, Shenzhen 518020, China; Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China; Department of Microbiology and Immunology, New York Medical College, Valhalla, NY 10510595, USA
Haiqiong Yu: Department of Allergy, The Third Affiliated Hospital of Shenzhen University, Shenzhen 518020, China
Peixin Ran: State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou 510006, China; Corresponding authors at: Department of Allergy, The Third Affiliated Hospital of Shenzhen University, Shenzhen 518020, China (Z. Liu) and State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou 510006, China (P. Ran).
Zhigang Liu: Department of Allergy, The Third Affiliated Hospital of Shenzhen University, Shenzhen 518020, China; Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China; Corresponding authors at: Department of Allergy, The Third Affiliated Hospital of Shenzhen University, Shenzhen 518020, China (Z. Liu) and State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou 510006, China (P. Ran).

Journal volume & issue: Vol. 52
pp. 611 – 619

Abstract

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Asthma is a common chronic inflammatory airway disorder associated with considerable morbidity, mortality and increased health care costs worldwide. Traditional Chinese medicine (TCM) as a functional food characterized by multi-compound and multi-target have been proven to be effective in treating asthma based on a holistic way. However, the potential molecular or systems mechanism of TCM to anti-asthma has not yet been fully elucidated. A systems pharmacology-based method combining the ADME evaluation, herb feature mapping, drug target fishing, network pharmacology, as well as pathway analysis is developed to comprehensively elucidate the potential therapeutic mechanism of asthma, exemplified by the anti-asthma herbal medicine intervention (ASHMI). Our study not only provides a comprehensive thinking for better understanding the complex action mechanism of ASHMI on asthma from a system level, but also proposed a rational novel way to facilitate the treatment of asthma.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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