Hypolipidaemic and antioxidant effects of functional cereal-mix produced with probiotic yeast in rats fed high cholesterol diet

Abstract

The effects of cereal-mix fermented with probiotic Pichia kudriavzevii OG32 on plasma antioxidant markers and serum and hepatic lipids in rats fed with high cholesterol diet were investigated. The groups fed on high cholesterol diet supplemented with probiotic cereal-mix had significantly higher levels of plasma antioxidant activity (trolox equivalent) and lower levels of serum total cholesterol, triacylglycerol and low density lipoprotein-cholesterol (LDL-C), when compared with the group fed high cholesterol diet without supplementation. Atherogenic index decreased from 1.94 ± 0.05 in positive control group to 0.66 ± 0.01 in HCD+10% CBFF fed group. High-cholesterol diet significantly increased the hepatic total cholesterol and triacylglycerol when compared to the negative control group, but the supplementation of the high cholesterol diet with different proportions of the fermented cereal-mix lowered the hepatic total cholesterol and triacylglycerol.

Keywords

• Pichia kudriavzevii
• Fermented cereal-mix
• Antioxidant activity
• Cholesterol