Three doses of BNT162b2 vaccine confer neutralising antibody capacity against the SARS-CoV-2 Omicron variant

Kevin K. Ariën; Leo Heyndrickx; Johan Michiels; Katleen Vereecken; Kurt Van Lent; Sandra Coppens; Betty Willems; Pieter Pannus; Geert A. Martens; Marjan Van Esbroeck; Maria E. Goossens; Arnaud Marchant; Koen Bartholomeeusen; Isabelle Desombere

doi:10.1038/s41541-022-00459-z

npj Vaccines (Mar 2022)

Three doses of BNT162b2 vaccine confer neutralising antibody capacity against the SARS-CoV-2 Omicron variant

Kevin K. Ariën,
Leo Heyndrickx,
Johan Michiels,
Katleen Vereecken,
Kurt Van Lent,
Sandra Coppens,
Betty Willems,
Pieter Pannus,
Geert A. Martens,
Marjan Van Esbroeck,
Maria E. Goossens,
Arnaud Marchant,
Koen Bartholomeeusen,
Isabelle Desombere

Affiliations

Kevin K. Ariën: Virology Unit, Department of Biomedical Sciences, Institute of Tropical Medicine Antwerp
Leo Heyndrickx: Virology Unit, Department of Biomedical Sciences, Institute of Tropical Medicine Antwerp
Johan Michiels: Virology Unit, Department of Biomedical Sciences, Institute of Tropical Medicine Antwerp
Katleen Vereecken: Virology Unit, Department of Biomedical Sciences, Institute of Tropical Medicine Antwerp
Kurt Van Lent: Department of Clinical Sciences, Institute of Tropical Medicine Antwerp
Sandra Coppens: Virology Unit, Department of Biomedical Sciences, Institute of Tropical Medicine Antwerp
Betty Willems: Virology Unit, Department of Biomedical Sciences, Institute of Tropical Medicine Antwerp
Pieter Pannus: SD Epidemiology and Public Health, Sciensano
Geert A. Martens: Department of Laboratory Medicine, AZ Delta General Hospital
Marjan Van Esbroeck: Department of Clinical Sciences, Institute of Tropical Medicine Antwerp
Maria E. Goossens: SD Epidemiology and Public Health, Sciensano
Arnaud Marchant: Institute for Medical Immunology and ULB Center for Research in Immunology (U-CRI), Université libre de Bruxelles (ULB)
Koen Bartholomeeusen: Virology Unit, Department of Biomedical Sciences, Institute of Tropical Medicine Antwerp
Isabelle Desombere: Immune response, SD Infectious Diseases in Humans, Sciensano

DOI: https://doi.org/10.1038/s41541-022-00459-z
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 3

Abstract

Read online

Abstract We report the levels of neutralising antibodies against Wuhan, Delta and Omicron variants in unimmunized infected (group 1), immunised and boosted (group 2) and infected immunised and boosted (group 3) adult individuals. Our observations support the rapid administration of a booster vaccine dose to prevent infection and disease caused by Omicron.

Published in npj Vaccines

ISSN: 2059-0105 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy; Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.nature.com/npjvaccines/

About the journal