Improvement of fucoxanthin oral efficacy via vehicles based on gum Arabic, gelatin and alginate hydrogel

Yang Li; Xiaoyu Dou; Jianhui Pang; Mengqi Liang; Chao Feng; Ming Kong; Ya Liu; Xiaojie Cheng; Ying Wang; Xiguang Chen

Journal of Functional Foods (Dec 2019)

Improvement of fucoxanthin oral efficacy via vehicles based on gum Arabic, gelatin and alginate hydrogel

Yang Li,
Xiaoyu Dou,
Jianhui Pang,
Mengqi Liang,
Chao Feng,
Ming Kong,
Ya Liu,
Xiaojie Cheng,
Ying Wang,
Xiguang Chen

Affiliations

Yang Li: College of Marine Life Science, Ocean University of China, 5# Yushan Road, Qingdao 266003, PR China
Xiaoyu Dou: College of Marine Life Science, Ocean University of China, 5# Yushan Road, Qingdao 266003, PR China
Jianhui Pang: College of Marine Life Science, Ocean University of China, 5# Yushan Road, Qingdao 266003, PR China
Mengqi Liang: College of Marine Life Science, Ocean University of China, 5# Yushan Road, Qingdao 266003, PR China
Chao Feng: College of Marine Life Science, Ocean University of China, 5# Yushan Road, Qingdao 266003, PR China
Ming Kong: College of Marine Life Science, Ocean University of China, 5# Yushan Road, Qingdao 266003, PR China
Ya Liu: College of Marine Life Science, Ocean University of China, 5# Yushan Road, Qingdao 266003, PR China
Xiaojie Cheng: College of Marine Life Science, Ocean University of China, 5# Yushan Road, Qingdao 266003, PR China
Ying Wang: The Research Center for Processing and Quality Control of Aquaculture Production, Marine Biology Institute of Shandong Province, 7# Youyun Road, Qingdao 266100, PR China
Xiguang Chen: College of Marine Life Science, Ocean University of China, 5# Yushan Road, Qingdao 266003, PR China; Qingdao National Laboratory for Marine Science and Technology, Qingdao 266000, PR China; Corresponding author at: College of Marine Life Science, Ocean University of China, 5# Yushan Road, Qingdao 266003, PR China.

Journal volume & issue: Vol. 63

Abstract

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The improvement of the stability of fucoxanthin in gastrointestinal tract is an important approach to enhance its edible efficacy. In this study, we designed complex carriers, which were composed by gum Arabic/gelatin microcapsules and alginate hydrogel beads (GA/GE/Alg-Beads), as gastric acid resistant vehicles for oral delivery of fucoxanthin. Various parameters of the obtained fucoxanthin loaded GA/GE/Alg-Beads (FX:GA/GE/Alg-Beads) were characterized. In vitro release rate assay showed that more than 90% of the encapsulated fucoxanthin was released in simulated intestine fluid (SIF), indicated the beads could protect fucoxanthin while incubated in simulated gastric fluid (SGF). In vivo oral efficacy assay exhibited that FX:GA/GE/Alg-Beads could more effectively lower the blood lipid and oxidative stress level of experimental mice than free fucoxanthin. These results demonstrated the beads are favorable oral delivery systems for fucoxanthin and other biologically active substances which are unstable in gastric acid.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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