Dose-dependent effects of apple pectin on alleviating high fat-induced obesity modulated by gut microbiota and SCFAs

Yuanyuan Zhao; Jinfeng Bi; Jianyong Yi; Jian Peng; Qiancheng Ma

Food Science and Human Wellness (Jan 2022)

Dose-dependent effects of apple pectin on alleviating high fat-induced obesity modulated by gut microbiota and SCFAs

Yuanyuan Zhao,
Jinfeng Bi,
Jianyong Yi,
Jian Peng,
Qiancheng Ma

Affiliations

Yuanyuan Zhao: Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences (CAAS)/Key Laboratory of Agro-Products Processing, Ministry of Agriculture and Rural Affairs, Beijing 100193, China
Jinfeng Bi: Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences (CAAS)/Key Laboratory of Agro-Products Processing, Ministry of Agriculture and Rural Affairs, Beijing 100193, China; Corresponding authors at: Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences (CAAS)/Key Laboratory of Agro-Products Processing, Ministry of Agriculture and Rural Affairs, Beijing 100193, China.
Jianyong Yi: Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences (CAAS)/Key Laboratory of Agro-Products Processing, Ministry of Agriculture and Rural Affairs, Beijing 100193, China; Corresponding authors at: Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences (CAAS)/Key Laboratory of Agro-Products Processing, Ministry of Agriculture and Rural Affairs, Beijing 100193, China.
Jian Peng: Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences (CAAS)/Key Laboratory of Agro-Products Processing, Ministry of Agriculture and Rural Affairs, Beijing 100193, China; Sericultural and Agri-Food Research Institute, Guangdong Academy of Agricultural Sciences/Guangdong Key Laboratory of Agricultural Products Processing, Guangzhou 510610, China
Qiancheng Ma: Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences (CAAS)/Key Laboratory of Agro-Products Processing, Ministry of Agriculture and Rural Affairs, Beijing 100193, China; School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China

Journal volume & issue: Vol. 11, no. 1
pp. 143 – 154

Abstract

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Recently, pectin has been used as an alternative for commercial prebiotic products to modulate gut microbiota. In this study, the standard diet (Chow group) and high fat diet containing 0% (HF group), 1%, 3%, 5%, 8% or 12% (m/m) apple pectin (HF-P group) were offered ad libitum for 8 weeks to 4-week C57BL/6J mice (n = 10/group). Results showed that body weight gain (R2 = –0.990), subcutaneous adipose accumulation (R2 = –0.930), serum triglyceride elevation (R2 = –0.879), acetate (R2 = 0.955) and propionate concentration reduction (R2 = 0.985) were suppressed by pectin from 1% to 12%, indicating dose response to pectin consumption. Moreover, abundance of obesity-related bacteria Coriobacteriaceae, and pectin-degradating bacteria, Faecalibaculum, Ruminococcus were significantly increased with pectin dosage increased, and the R2 were 0.936, 0.963 and 0.937, respectively. Besides, attenuations for colonic injury and liver steatosis were observed after adding 5% and 8% pectin, respectively. This study confirmed the dose-sensitive manner of pectin to alleviate HF-induced obesity by modulating gut microbiota and enhancing short-chain fatty acids production.

Published in Food Science and Human Wellness

ISSN: 2097-0765 (Print); 2213-4530 (Online)
Publisher: Tsinghua University Press
Country of publisher: China
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.sciopen.com/journal/2097-0765

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