The acute effect of the antioxidant drug “U-74389G” on red blood cells levels during hypoxia reoxygenation injury in rats

Abstract

Objective: To examine the effect of the antioxidant drug “U-74389G”, on rat model and particularly in a hypoxia reoxygenation (HR) protocol. The beneficial effect or non-effectiveness of that molecule was studied hematologically using mean red blood cells levels. Methods: 40 rats of mean weight 231.875 g were used in the study. Red blood cells levels were measured 60 min after reoxygenation (groups A and C) and 120 min after reoxygenation (groups B and D) with administration of the drug U-74389G only in groups C and D. Results: U-74389G administration non-significantly increased the red blood cells level by (0.64±0.32)% (P=0.810 6). Reoxygenation time also non-significantly increased the red blood cells level by (4.63±2.36)% (P=0.068 0). However, U-74389G administration and reoxygenation time together non-significantly increased the red blood cells level by (1.05±0.53)% (P=0.491 1). Conclusions: Results of this study show that U-74389G administration, reoxygenation time and their interaction non significantly increased the red blood cells levels within 2 hours' time interval.

Keywords

• Hypoxia
• Reoxygenation
• U-74389G
• Red blood cells