Effect of soluble dietary fiber on gut microbiota and derived metabolites in stage 3 to 5 chronic kidney disease patients: A randomized controlled trial

Yuan Cui; Dingwei Kuang; Jing Wang; Shaoye Huo; Peng Li; Lin Lu; Yuhuan Wei; Lihong Wang; Xiaojing Zhong; Yunhua Zhao; Jianying Niu; Weibing Wang; Chunhai Shao

Journal of Functional Foods (May 2024)

Effect of soluble dietary fiber on gut microbiota and derived metabolites in stage 3 to 5 chronic kidney disease patients: A randomized controlled trial

Yuan Cui,
Dingwei Kuang,
Jing Wang,
Shaoye Huo,
Peng Li,
Lin Lu,
Yuhuan Wei,
Lihong Wang,
Xiaojing Zhong,
Yunhua Zhao,
Jianying Niu,
Weibing Wang,
Chunhai Shao

Affiliations

Yuan Cui: Department of Nutrition, Shanghai Fifth People’s Hospital, Fudan University, Shanghai 200240, China
Dingwei Kuang: Department of Nephrology, Huashan Hospital, Fudan University, Shanghai 200040, China
Jing Wang: Department of Nutrition, Huashan Hospital, Fudan University, Shanghai 200040, China
Shaoye Huo: Department of Nutrition, Shanghai Fifth People’s Hospital, Fudan University, Shanghai 200240, China
Peng Li: Department of Nephrology, Shanghai Fifth People’s Hospital, Fudan University, Shanghai 200240, China
Lin Lu: Department of Nephrology, Huashan Hospital, Fudan University, Shanghai 200040, China
Yuhuan Wei: Department of Nutrition, Shanghai Fifth People’s Hospital, Fudan University, Shanghai 200240, China
Lihong Wang: Department of Nutrition, Shanghai Fifth People’s Hospital, Fudan University, Shanghai 200240, China
Xiaojing Zhong: Department of Nephrology, Shanghai Fifth People’s Hospital, Fudan University, Shanghai 200240, China
Yunhua Zhao: Department of Nutrition, Shanghai Fifth People’s Hospital, Fudan University, Shanghai 200240, China
Jianying Niu: Department of Nephrology, Shanghai Fifth People’s Hospital, Fudan University, Shanghai 200240, China; Corresponding author at: Department of Nutrition, Shanghai Fifth People’s Hospital, Fudan University, No. 801 Heqing Road, Minhang District, Shanghai 200240, China (C. Shao). Department of Nephrology, Shanghai Fifth People’s Hospital, Fudan University (J. Niu). Department of Epidemiology, School of Public Health, Fudan University (W. Wang).
Weibing Wang: Department of Epidemiology, School of Public Health, Fudan University, Shanghai 200032, China; Corresponding author at: Department of Nutrition, Shanghai Fifth People’s Hospital, Fudan University, No. 801 Heqing Road, Minhang District, Shanghai 200240, China (C. Shao). Department of Nephrology, Shanghai Fifth People’s Hospital, Fudan University (J. Niu). Department of Epidemiology, School of Public Health, Fudan University (W. Wang).
Chunhai Shao: Department of Nutrition, Shanghai Fifth People’s Hospital, Fudan University, Shanghai 200240, China; Department of Nutrition, Huashan Hospital, Fudan University, Shanghai 200040, China; Department of Epidemiology, School of Public Health, Fudan University, Shanghai 200032, China; Corresponding author at: Department of Nutrition, Shanghai Fifth People’s Hospital, Fudan University, No. 801 Heqing Road, Minhang District, Shanghai 200240, China (C. Shao). Department of Nephrology, Shanghai Fifth People’s Hospital, Fudan University (J. Niu). Department of Epidemiology, School of Public Health, Fudan University (W. Wang).

Journal volume & issue: Vol. 116
p. 106181

Abstract

Read online

Gut dysbiosis is closely associated with the burden of chronic kidney disease (CKD), and strategies such as prebiotic supplementation have been suggested to ameliorate CKD and related complications. We hypothesized that prebiotic-soluble dietary fiber (SDF) complexes could ameliorate biochemical parameters, gut microbiota and microbial metabolites of CKD. Here, forty non-dialyzed CKD patients in stage 3 to 5 were randomized to receive either SDF or placebo for 30 days. As expected, SDF intervention reduced serum total cholesterol levels (P＜0.05) and plasma interleukin (IL)-8 levels (P＜0.05). No profound changes in the diversity or community structure of the gut microbiota were observed in SDF group, but the composition of the gut microbiota was altered. Moreover, the concentration of propionate of short-chain fatty acids (SCFAs) increased significantly following SDF intervention (P＜0.05). SDF supplementation seems to be a promising strategy to improve inflammation, gut microbiology and derived metabolites.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

About the journal

Abstract

Keywords