Pterostilbene exerts anti-neuroinflammatory effect on lipopolysaccharide-activated microglia via inhibition of MAPK signalling pathways

Yue Hou; Ning Li; Guanbo Xie; Jian Wang; Qing Yuan; Congcong Jia; Xia Liu; Guoxun Li; Yingzhan Tang; Bing Wang

Journal of Functional Foods (Dec 2015)

Pterostilbene exerts anti-neuroinflammatory effect on lipopolysaccharide-activated microglia via inhibition of MAPK signalling pathways

Yue Hou,
Ning Li,
Guanbo Xie,
Jian Wang,
Qing Yuan,
Congcong Jia,
Xia Liu,
Guoxun Li,
Yingzhan Tang,
Bing Wang

Affiliations

Yue Hou: College of Life and Health Sciences, Northeastern University, Shenyang 110004, China
Ning Li: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Ministry of Education, Shenyang 110016, China; Key Laboratory of Structure-Based Drug Design and Discovery, Shenyang Pharmaceutical University, Ministry of Education, Shenyang 110016, China; Corresponding author. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China. Tel.: +86 24 23986475; fax: +86 24 23986479.
Guanbo Xie: The 307th Hospital of Chinese People's Liberation Army, Beijing 100071, China
Jian Wang: Key Laboratory of Structure-Based Drug Design and Discovery, Shenyang Pharmaceutical University, Ministry of Education, Shenyang 110016, China; School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China
Qing Yuan: College of Life and Health Sciences, Northeastern University, Shenyang 110004, China
Congcong Jia: College of Life and Health Sciences, Northeastern University, Shenyang 110004, China
Xia Liu: College of Life and Health Sciences, Northeastern University, Shenyang 110004, China
Guoxun Li: College of Life and Health Sciences, Northeastern University, Shenyang 110004, China
Yingzhan Tang: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Ministry of Education, Shenyang 110016, China; Key Laboratory of Structure-Based Drug Design and Discovery, Shenyang Pharmaceutical University, Ministry of Education, Shenyang 110016, China
Bing Wang: College of Life and Health Sciences, Northeastern University, Shenyang 110004, China; Corresponding author. College of Life and Health Sciences, Northeastern University, Shenyang 110004, China. Tel.: +86 24 83656116; fax: +86 24 83656120.

Journal volume & issue: Vol. 19
pp. 676 – 687

Abstract

Read online

The present study investigated the anti-neuroinflammatory effect of pterostilbene. The data demonstrated that pterostilbene significantly suppresses lipopolysaccharide (LPS)-induced nitric oxide (NO) production and iNOS mRNA expression in BV-2 microglial cells. Pterostilbene significantly inhibits LPS-induced IL-6 and TNF-α production and mRNA expression and the phosphorylation of MAPKs. The effect of pterostilbene on neuroinflammation was further confirmed in vivo using a rat neuroinflammation model. Immunohistochemical study indicated that pterostilbene mitigates LPS-induced microglial activation in rat hippocampal CA1 and dentate gyrus (DG). Pterostilbene significantly inhibits LPS-induced IL-6 and TNF-α mRNA expression in rat hippocampus and their amount in rat serum. This study demonstrated that pterostilbene possesses anti-neuroinflammatory property, suggesting its potential as a dietary supplement that benefits neurodegenerative diseases associated with neuroinflammation.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

About the journal

Abstract

Keywords