Differential regulation of host immunity, microbiota, and metabolism by planktonic and biofilm cells of Lactiplantibacillus paraplantarum LR-1

Lei Liu; Xing Chen; Xiaoyu Yin; Yao Yang; Lu Yuan; Hang Xiao; Yu Rao

Journal of Functional Foods (Oct 2023)

Differential regulation of host immunity, microbiota, and metabolism by planktonic and biofilm cells of Lactiplantibacillus paraplantarum LR-1

Lei Liu,
Xing Chen,
Xiaoyu Yin,
Yao Yang,
Lu Yuan,
Hang Xiao,
Yu Rao

Affiliations

Lei Liu: State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730000, China; School of Food Science and Bioengineering, Xihua University, Chengdu 610039, China
Xing Chen: State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730000, China; School of Food Science and Bioengineering, Xihua University, Chengdu 610039, China
Xiaoyu Yin: State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730000, China; School of Food Science and Bioengineering, Xihua University, Chengdu 610039, China
Yao Yang: State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730000, China; School of Food Science and Bioengineering, Xihua University, Chengdu 610039, China
Lu Yuan: State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730000, China; School of Food Science and Bioengineering, Xihua University, Chengdu 610039, China
Hang Xiao: Department of Food Science, University of Massachusetts, Amherst, MA 01003, USA; Corresponding authors.
Yu Rao: School of Food Science and Bioengineering, Xihua University, Chengdu 610039, China; Corresponding authors.

Journal volume & issue: Vol. 109
p. 105779

Abstract

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Probiotics are receiving significant attention due to their considerable health advantages. However, research involving the effect of probiotic biofilm and planktonic cells on the health of the host is limited. This study ascertained that the biofilm cells of Lactiplantibacillus paraplantarum LR-1 displayed stronger immunomodulation activity than their planktonic counterparts. Furthermore, the LR-1 biofilm cells more distinctly influenced the relative abundance of the intestinal marker bacteria than the planktonic cells. In comparison to the planktonic cells and the control group, the biofilm cells exhibited a stronger potential positive effect on the metabolism of the mice. Correlation analysis revealed the interaction between the metabolites, genera, and immune factors, which could explain the mechanism behind the beneficial effect of LR-1 biofilm or planktonic cells on host health. The results of this study enhance the understanding of the beneficial impact of probiotic biofilm cells while providing references for further investigation.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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