Anti-hyperglycemic effects of dihydromyricetin in streptozotocin-induced diabetic rats

Maojun Yao; Hui Teng; Qiyan Lv; Huifang Gao; Tengming Guo; Yiwen Lin; Sihai Gao; Meihu Ma; Lei Chen

Food Science and Human Wellness (Mar 2021)

Anti-hyperglycemic effects of dihydromyricetin in streptozotocin-induced diabetic rats

Maojun Yao,
Hui Teng,
Qiyan Lv,
Huifang Gao,
Tengming Guo,
Yiwen Lin,
Sihai Gao,
Meihu Ma,
Lei Chen

Affiliations

Maojun Yao: College of Chemistry and Chemical Engineering, Jishou University, Jishou, 416000, China; National Research and Development Center for Egg Processing, College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, Hubei, China
Hui Teng: College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China; College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524025, China
Qiyan Lv: College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China
Huifang Gao: College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China
Tengming Guo: College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China
Yiwen Lin: College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China
Sihai Gao: Department of Cardiothoracic and Vascular Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China; Corresponding authors.
Meihu Ma: National Research and Development Center for Egg Processing, College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, Hubei, China; Corresponding authors.
Lei Chen: College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian 350002, China; College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524025, China; Corresponding authors.

Journal volume & issue: Vol. 10, no. 2
pp. 155 – 162

Abstract

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Dihydromyricetin (DHM), as a bioactive flavanonol compound, is mainly found in “Tengcha” (Ampelopsis grossedentata) cultivated in south of China. This study aimed to investigate the anti-hyperglycemic and anti-dyslipidemic activities of DHM using type 2 diabetes mellitus (T2D) rats, which was induced by feeding with high fat and fructose diet for 42 days and intraperitoneal administration of streptozocin. Forty-eight freshly-weaned rats were randomly assigned into the negative control (Blank), low dose (100 mg/kg), medium dose (200 mg/kg), high dose (400 mg/kg), and positive (40 mg/kg, met) groups. Fasting blood glucose and body weight were measured at weekly interval. Oral glucose tolerance tests were performed on days 42. The results revealed that DHM possessed significant antihyperglycaemic and antihyperinsulinemic effects. Moreover, after the DHM treatment, p-Akt and p-AMPK expression was upregulated, and glycogen synthase kinase-3β (GSK-3β) expression was downregulated, indicating that the potential anti-diabetic mechanism of DHM might be due to the regulation of the AMPK/Akt/GSK-3β signaling pathway.

Published in Food Science and Human Wellness

ISSN: 2213-4530 (Online)
Publisher: Tsinghua University Press
Country of publisher: China
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.sciopen.com/journal/2097-0765

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