Nutrition and Dietary Supplements (Feb 2021)
Potential Nutraceuticals for COVID-19
Abstract
Sayali Savant, Shraddha Srinivasan, Anil Kumar Kruthiventi Arna Immuno Ingredients Private Limited, Mumbai, Maharashtra, IndiaCorrespondence: Anil Kumar KruthiventiArna Immuno Ingredients Private Limited, 1st Floor, 41/44, Minoo Desai Marg, Colaba, Mumbai, 400005, IndiaTel +91 954 550 0481Fax +91 22 674 900 001Email [email protected]: SARS-CoV-2 infection has caused, and is continuing to cause, considerable human suffering. Studies on the viral pathogenesis has resulted in convergent findings from several lines of evidence on the entry and spread of the virus in the host. These studies have also revealed a strong association between innocuous inflammation, ageing and metabolic disorders, with SARS-CoV-2 infection and its prognosis. Diet helps modulate inflammation, and nutraceuticals can inhibit viral entry. Hence, we have collated literature on antiviral nutraceuticals effective against other similar coronaviruses. The objective of this study is to comprehensively review available information on the antiviral activity of nutraceuticals and to discuss the implications of these findings in designing a diet that would boost the innate immunity and act as preventive care against COVID-19. This review highlights the fundamental impact of nutraceuticals and diet on inhibition of viral entry and provides a new perspective on the prevention and treatment of COVID-19.Keywords: SARS-CoV-2, diet, plant protease inhibitors, polyphenols, bioactive peptides
