Bioactive Compounds from and against Yeasts in the One Health Context: A Comprehensive Review
Viviani Tadioto,
Anderson Giehl,
Rafael Dorighello Cadamuro,
Iara Zanella Guterres,
Angela Alves dos Santos,
Stefany Kell Bressan,
Larissa Werlang,
Boris U. Stambuk,
Gislaine Fongaro,
Izabella Thaís Silva,
Sérgio Luiz Alves
Affiliations
Viviani Tadioto
Graduate Program in Biotechnology and Biosciences, Federal University of Santa Catarina, Florianópolis 88040-900, SC, Brazil
Anderson Giehl
Graduate Program in Biotechnology and Biosciences, Federal University of Santa Catarina, Florianópolis 88040-900, SC, Brazil
Rafael Dorighello Cadamuro
Graduate Program in Biotechnology and Biosciences, Federal University of Santa Catarina, Florianópolis 88040-900, SC, Brazil
Iara Zanella Guterres
Laboratory of Applied Virology, Department of Microbiology, Immunology, and Parasitology, Federal University of Santa Catarina, Florianópolis 88040-900, SC, Brazil
Angela Alves dos Santos
Laboratory of Yeast Molecular Biology and Biotechnology, Department of Biochemistry, Federal University of Santa Catarina, Florianópolis 88040-900, SC, Brazil
Stefany Kell Bressan
Laboratory of Yeast Biochemistry, Federal University of Fronteira Sul, Campus Chapecó 89815-899, SC, Brazil
Larissa Werlang
Laboratory of Yeast Biochemistry, Federal University of Fronteira Sul, Campus Chapecó 89815-899, SC, Brazil
Boris U. Stambuk
Graduate Program in Biotechnology and Biosciences, Federal University of Santa Catarina, Florianópolis 88040-900, SC, Brazil
Gislaine Fongaro
Graduate Program in Biotechnology and Biosciences, Federal University of Santa Catarina, Florianópolis 88040-900, SC, Brazil
Izabella Thaís Silva
Graduate Program in Biotechnology and Biosciences, Federal University of Santa Catarina, Florianópolis 88040-900, SC, Brazil
Sérgio Luiz Alves
Graduate Program in Biotechnology and Biosciences, Federal University of Santa Catarina, Florianópolis 88040-900, SC, Brazil
Yeasts are the most used microorganisms for biotechnological purposes. Although they have been mainly recognized for their application in the beverage and bioethanol industries, these microorganisms can be efficiently employed in pharmaceutical and food production companies. In these industrial sectors, yeasts are highly desirable for their capacity to produce bioactive compounds from simple substrates, including wastes. In this review, we present the state of the art of bioactive compound production in microbial cell factories and analyze the avenues to increase the productivity of these molecules, which benefit human and environmental health. The article addresses their vast biological activities, from preventing to treating human diseases and from pre to postharvest control on agroindustrial streams. Furthermore, different yeast species, genetically engineered or not, are herein presented not only as biofactories of the referred to compounds but also as their targets. This comprehensive analysis of the literature points out the significant roles of biodiversity, bioprospection, and genome editing tools on the microbial production of bioactive compounds and reveals the value of these approaches from the one health perspective.