Icariside II alleviates ischemic retinopathy by modulating microglia and promoting vessel integrity

Dan Yan; Qian Wu; Xiuchun Li; Qian Chen; Caihong Huang; Jiaoyue Hu; Zuguo Liu

Journal of Functional Foods (May 2023)

Icariside II alleviates ischemic retinopathy by modulating microglia and promoting vessel integrity

Dan Yan,
Qian Wu,
Xiuchun Li,
Qian Chen,
Caihong Huang,
Jiaoyue Hu,
Zuguo Liu

Affiliations

Dan Yan: School of Medicine, Xiamen University, Xiamen, Fujian 361005, China; Department of Ophthalmology, Xiang'an Hospital of Xiamen University, Eye Institute of Xiamen University, Xiamen, Fujian 361005, China; Xiamen University affiliated Xiamen Eye Center, Xiamen, Fujian 361100, China
Qian Wu: School of Medicine, Xiamen University, Xiamen, Fujian 361005, China; Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, China
Xiuchun Li: Division of Pulmonary Medicine, the First Affiliated Hospital of Wenzhou Medical University, Key Laboratory of Heart and Lung, Wenzhou, China
Qian Chen: School of Medicine, Xiamen University, Xiamen, Fujian 361005, China; Department of Ophthalmology, Xiang'an Hospital of Xiamen University, Eye Institute of Xiamen University, Xiamen, Fujian 361005, China; Xiamen University affiliated Xiamen Eye Center, Xiamen, Fujian 361100, China
Caihong Huang: School of Medicine, Xiamen University, Xiamen, Fujian 361005, China; Department of Ophthalmology, Xiang'an Hospital of Xiamen University, Eye Institute of Xiamen University, Xiamen, Fujian 361005, China; Xiamen University affiliated Xiamen Eye Center, Xiamen, Fujian 361100, China
Jiaoyue Hu: School of Medicine, Xiamen University, Xiamen, Fujian 361005, China; Department of Ophthalmology, Xiang'an Hospital of Xiamen University, Eye Institute of Xiamen University, Xiamen, Fujian 361005, China; Xiamen University affiliated Xiamen Eye Center, Xiamen, Fujian 361100, China; Corresponding authors at: School of Medicine, Xiamen University, Xiamen, Fujian 361005, China.
Zuguo Liu: School of Medicine, Xiamen University, Xiamen, Fujian 361005, China; Department of Ophthalmology, Xiang'an Hospital of Xiamen University, Eye Institute of Xiamen University, Xiamen, Fujian 361005, China; Xiamen University affiliated Xiamen Eye Center, Xiamen, Fujian 361100, China; Department of Ophthalmology, the First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, China; Corresponding authors at: School of Medicine, Xiamen University, Xiamen, Fujian 361005, China.

Journal volume & issue: Vol. 104
p. 105510

Abstract

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Ischemic retinopathies (IRs) are vision-threatening diseases that affect a substantial amount of people. The current treatment options for IRs have side effects and are unable to prevent disease progression. It is therefore worthwhile to consider alternative treatments that could be safer and more efficient. Icariside II (IRS) is a metabolite icariin, derived from traditional Chinese medicine Herba Epimedii. In the oxygen-induced retinopathy (OIR) model, IRS significantly inhibited pathological angiogenesis and retinal hemorrhage dose-dependently. Its efficacy could be regulated by glycogen synthase kinase-3β (GSK-3β) and β-catenin, which may be critical roles in suppression of the activated microglia and exacerbation of pathologic angiogenic process. These results suggest that intake of IRS can be a potentially effective treatment in IRs via promoting the proper angiogenesis architecturally and functionally.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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