Phosphorylated peptides from Antarctic krill (Euphausia superba) ameliorated osteoporosis by activation of osteogenesis-related MAPKs and PI3K/AKT/GSK-3β pathways in dexamethasone-treated mice

Lihua Han; Xiangzhao Mao; Kai Wang; Yuanyuan Li; Meihui Zhao; Jingfeng Wang; Changhu Xue

Journal of Functional Foods (Aug 2018)

Phosphorylated peptides from Antarctic krill (Euphausia superba) ameliorated osteoporosis by activation of osteogenesis-related MAPKs and PI3K/AKT/GSK-3β pathways in dexamethasone-treated mice

Lihua Han,
Xiangzhao Mao,
Kai Wang,
Yuanyuan Li,
Meihui Zhao,
Jingfeng Wang,
Changhu Xue

Affiliations

Lihua Han: College of Food Science and Engineering, Ocean University of China, Qingdao, Shandong Province, 266003, China
Xiangzhao Mao: College of Food Science and Engineering, Ocean University of China, Qingdao, Shandong Province, 266003, China
Kai Wang: College of Food Science and Engineering, Ocean University of China, Qingdao, Shandong Province, 266003, China
Yuanyuan Li: College of Food Science and Engineering, Ocean University of China, Qingdao, Shandong Province, 266003, China
Meihui Zhao: College of Food Science and Engineering, Ocean University of China, Qingdao, Shandong Province, 266003, China
Jingfeng Wang: Corresponding authors at: College of Food Science and Engineering, Ocean University of China, No.5 Yushan Road, Qingdao, Shandong Province 266003, China.; College of Food Science and Engineering, Ocean University of China, Qingdao, Shandong Province, 266003, China
Changhu Xue: Corresponding authors at: College of Food Science and Engineering, Ocean University of China, No.5 Yushan Road, Qingdao, Shandong Province 266003, China.; College of Food Science and Engineering, Ocean University of China, Qingdao, Shandong Province, 266003, China

Journal volume & issue: Vol. 47
pp. 447 – 456

Abstract

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In this study, the effects of phosphorylated peptides from Antarctic krill (PP-AKP) on osteoporosis induced by dexamethasone were investigated in vivo. Results showed that PP-AKP significantly improved bone turnover status, reduced bone loss and degeneration of microarchitecture, in addition to accelerated bone formation. Further mechanism investigation revealed that PP-AKP suppressed the mRNA expression of MKP-1 and CB1, which activated the downstream osteogenesis-related MAPKs and PI3K/AKT/GSK-3β signaling pathways through elevation of the expression of the key factors p38, ERK, PI3K, AKT and β-catenin, in addition to osteogenic nuclear transcription factors Runx2 and OSX. Additionally, reduction in number of adipocytes and an increase in trabeculae in the bone marrow cavity, in addition to a decrease in abdominal adipose further verified that PP-AKP augmented bone formation with a comparable reduction in the accumulation of fat. In conclusion, PP-AKP ameliorated osteoporosis via promoting MAPKs and PI3K/AKT/GSK-3β pathways related to bone formation in dexamethasone-treated mice.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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