Oyster hydrolysate-zinc complex ameliorates carrageenan-induced rat prostatitis via an anti-inflammatory mechanism and reduced oxidative stress

Abstract

Nonbacterial prostatitis has been reported to be associated with reduced zinc intake, but the role of zinc remains unclear. Here, oyster hydrolysate-zinc complex (OH-Zn) was prepared to attenuate rat prostatitis. We found using dynamic light scattering and energy-dispersive X-ray analysis that OH-Zn was a nanostructure complex (49.06 ± 0.26 nm) with a prominent signal of zinc. Fourier transform infrared spectroscopy illustrated that OH-Zn was formed via interactions among zinc ions, amino nitrogen atoms and carboxyl oxygen. OH-Zn treatment significantly reduced the prostatic index value, prostatic specific antigen, tumor necrosis factor-alpha, interleukin-1 beta, malonaldehyde, prostatic acid phosphatase, and acid phosphatase in prostatitis rats. OH-Zn increased the levels of superoxide dismutase, glutathione and serum zinc concentration in prostatitis rats relative to the control group. Moreover, histological analyses revealed OH-Zn prevented the carrageen-induced pathological morphology of the prostate. Therefore, OH-Zn might be a preferable paradigm to ameliorate prostatitis as a novel zinc supplement.

Keywords

• Nonbacterial prostatitis
• Oyster hydrolysates
• Hydrolysate-zinc complex
• Zinc intake
• Amelioration effect