Nature Communications (2016-12-01)

Evolution of multiple cell clones over a 29-year period of a CLL patient

  • Zhikun Zhao,
  • Lynn Goldin,
  • Shiping Liu,
  • Liang Wu,
  • Weiyin Zhou,
  • Hong Lou,
  • Qichao Yu,
  • Shirley X. Tsang,
  • Miaomiao Jiang,
  • Fuqiang Li,
  • MaryLou McMaster,
  • Yang Li,
  • Xinxin Lin,
  • Zhifeng Wang,
  • Liqin Xu,
  • Gerald Marti,
  • Guibo Li,
  • Kui Wu,
  • Meredith Yeager,
  • Huanming Yang,
  • Xun Xu,
  • Stephen J. Chanock,
  • Bo Li,
  • Yong Hou,
  • Neil Caporaso,
  • Michael Dean

DOI
https://doi.org/10.1038/ncomms13765
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 10

Abstract

Read online

Studying the genetic progression of many cancers is difficult as longitudinal samples are rarely available. Here, the authors analyse a patient with chronic lymphocytic leukaemia over a 29 year period and track the clonal evolution of the patient’s disease and response to therapy.