Bovine α-lactalbumin hydrolysates (α-LAH) attenuate high-fat diet induced nonalcoholic fatty liver disease by modulating hepatic lipid metabolism in C57BL/6J mice

Jing Gao; Jiajia Song; Min Du; Xueying Mao

Journal of Functional Foods (Mar 2019)

Bovine α-lactalbumin hydrolysates (α-LAH) attenuate high-fat diet induced nonalcoholic fatty liver disease by modulating hepatic lipid metabolism in C57BL/6J mice

Jing Gao,
Jiajia Song,
Min Du,
Xueying Mao

Affiliations

Jing Gao: Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science & Nutritional Engineering, China Agricultural University, Beijing, China; College of Food Science and Nutritional Engineering, Key Laboratory of Functional Dairy, Ministry of Education, China Agricultural University, Beijing, China
Jiajia Song: Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science & Nutritional Engineering, China Agricultural University, Beijing, China; College of Food Science and Nutritional Engineering, Key Laboratory of Functional Dairy, Ministry of Education, China Agricultural University, Beijing, China
Min Du: Department of Animal Science, Washington State University, Pullman, WA, USA
Xueying Mao: Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science & Nutritional Engineering, China Agricultural University, Beijing, China; College of Food Science and Nutritional Engineering, Key Laboratory of Functional Dairy, Ministry of Education, China Agricultural University, Beijing, China; Corresponding author at: Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, Key Laboratory of Functional Dairy, Ministry of Education, China Agricultural University, 100083 Beijing, China.

Journal volume & issue: Vol. 54
pp. 254 – 262

Abstract

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The effect of bovine α-lactalbumin hydrolysates (α-LAH) on attenuating high-fat diet (HFD) induced nonalcoholic fatty liver disease (NAFLD) was investigated. C57BL/6J mice were fed with HFD for 8 weeks to mimic the clinical features of NAFLD, and then were fed with HFD and bovine α-LAH at different doses (100, 200 and 400 mg/kg b.w.) for another 12 weeks to investigate the beneficial effects of bovine α-LAH on NAFLD. Our data showed that bovine α-LAH markedly reversed the increase of body weight gain, tissue weight, serum lipids, liver injury markers, and serum pro-inflammatory cytokines induced by HFD in C57BL/6J mice. Bovine α-LAH supplementation also ameliorated fat accumulation and oxidative stress, down-regulated PPARγ associated gene expression, and up-regulated PPARα associated gene expression in the liver of mice fed HFD. These findings suggested that bovine α-LAH is effective in attenuating HFD induced NAFLD in C57BL/6J mice.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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