npj Vaccines (Oct 2023)

mRNA vaccine encoding Gn provides protection against severe fever with thrombocytopenia syndrome virus in mice

  • Jae-Yong Kim,
  • Kyeongseok Jeon,
  • Sang-In Park,
  • Yoo-Jin Bang,
  • Hyeong-Jun Park,
  • Hye Won Kwak,
  • Do-Hyung Kim,
  • Soo-Yeon Lee,
  • Eun-Jin Choi,
  • Nam-Hyuk Cho,
  • Jae-Hwan Nam

DOI
https://doi.org/10.1038/s41541-023-00771-2
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 5

Abstract

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Abstract We developed a promising mRNA vaccine against severe fever with thrombocytopenia syndrome (SFTS), an infectious disease caused by the SFTS virus that is primarily transmitted through tick bites. Administration of lipid nanoparticle-encapsulated mRNA-Gn successfully induced neutralizing antibodies and T-cell responses in mice. The vaccinated mice were protected against a lethal SFTS virus challenge, suggesting that this mRNA vaccine may be an effective and successful SFTS vaccine candidate.