Polysaccharides from Panax ginseng C. A. Meyer alleviated DSS-induced IBD by inhibiting JAK2/STAT1/NLPR3 inflammasome signalling pathway in mice

Abstract

Panax ginseng polysaccharides (GPS) are isolated from Panax ginseng C. A. Meyer, which has many pharmacological activities. However, although the protective effect of GPS on inflammatory bowel disease (IBD) has been characterized, its mechanism has not yet been fully elucidated. In the present study, we clarified it effect on IBD in mice and studied the mechanism of reducing inflammation. IBD model was established in mice by administrating dextran sulfate sodium (DSS) in drinking water for 7 days. Our results showed that GPS treatment significantly relieved disease activity index, colon length shortening and pathological changes in colonic tissue. Furthermore, GPS treatment significantly reduced oxidative stress and inflammatory cytokines in the colonic tissue via inhibiting JAK2/STAT1/NLRP3 inflammasome signalling pathway. In conclusion, these results demonstrated that GPS could attenuate inflammatory response via inhibiting JAK2/STAT1/NLPR3 inflammasome signalling pathway. Hence, GPS may be a potential natural medicine to inhibit JAK2/STAT1/NLRP3 inflammasome signalling pathway and reduce inflammation in IBD.

Keywords

• Panax ginseng polysaccharides
• IBD
• NLRP3 inflammasome
• JAK2/STAT1 signalling pathway