Polysaccharides from the flowers of tea (Camellia sinensis L.) modulate gut health and ameliorate cyclophosphamide-induced immunosuppression

Dan Chen; Guijie Chen; Yu Ding; Peng Wan; Yujia Peng; Chunxu Chen; Hong Ye; Xiaoxiong Zeng; Linwu Ran

Journal of Functional Foods (Oct 2019)

Polysaccharides from the flowers of tea (Camellia sinensis L.) modulate gut health and ameliorate cyclophosphamide-induced immunosuppression

Dan Chen,
Guijie Chen,
Yu Ding,
Peng Wan,
Yujia Peng,
Chunxu Chen,
Hong Ye,
Xiaoxiong Zeng,
Linwu Ran

Affiliations

Dan Chen: College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, People’s Republic of China
Guijie Chen: College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, People’s Republic of China
Yu Ding: College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, People’s Republic of China
Peng Wan: College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, People’s Republic of China
Yujia Peng: College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, People’s Republic of China
Chunxu Chen: College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, People’s Republic of China
Hong Ye: College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, People’s Republic of China
Xiaoxiong Zeng: College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, People’s Republic of China; Corresponding authors.
Linwu Ran: Laboratory Animal Center, Ningxia Medical University, Yinchuan 750004, Ningxia, People’s Republic of China; Corresponding authors.

Journal volume & issue: Vol. 61

Abstract

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Polysaccharides are closely related to immune regulation, however, the effects of polysaccharides from different sources may be different. Therefore, the impact of a pectic heteropolysaccharides (TFPS) from the flowers of tea (Camellia sinensis L.) plant on immunoregulation and possible mechanisms were investigated by using cyclophosphamide (Cy)-induced BALB/c mice in the present study. TFPS especially at the dosage of 200 mg/kg·BW/d could stimulate the immunoreaction. TFPS could activate the colonic TLR4/MyD88/NF-κB p65 and JAK2/STAT3 pathways and enhance the expression of intestinal mucosal integrity genes including Claudin1, Claudin5 and Occludin1 at mRNA level, and histologically improve the intestinal barrier. TFPS remarkably reversed 69 of total 80 genera and 17 of 20 bacterial functional KEGG pathways related to immune system, and promoted the production of short-chain fatty acids in Cy-induced immunocompromised mice. The results indicate that gut health is crucial to host’s immunoreaction.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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