Anti-neuroinflammatory and NQO1 inducing activity of natural phytochemicals from Coreopsis tinctoria

Ning Li; Dali Meng; Ying Pan; Qingling Cui; Guoxun Li; Hui Ni; Yu Sun; Degang Qing; Xiaoguang Jia; Yingni Pan; Yue Hou

Journal of Functional Foods (Aug 2015)

Anti-neuroinflammatory and NQO1 inducing activity of natural phytochemicals from Coreopsis tinctoria

Ning Li,
Dali Meng,
Ying Pan,
Qingling Cui,
Guoxun Li,
Hui Ni,
Yu Sun,
Degang Qing,
Xiaoguang Jia,
Yingni Pan,
Yue Hou

Affiliations

Ning Li: School of Traditional Chinese Materia Medica 49#, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, China; Key Laboratory of Structure-Based Drug Design and Discovery, Shenyang Pharmaceutical University, Ministry of Education, Wenhua Road 103, Shenyang 110016, China
Dali Meng: School of Traditional Chinese Materia Medica 49#, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, China; Key Laboratory of Structure-Based Drug Design and Discovery, Shenyang Pharmaceutical University, Ministry of Education, Wenhua Road 103, Shenyang 110016, China
Ying Pan: School of Traditional Chinese Materia Medica 49#, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, China; Key Laboratory of Structure-Based Drug Design and Discovery, Shenyang Pharmaceutical University, Ministry of Education, Wenhua Road 103, Shenyang 110016, China
Qingling Cui: School of Traditional Chinese Materia Medica 49#, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, China
Guoxun Li: College of Life and Health Sciences, Northeastern University, Shenyang 110004, China
Hui Ni: XinJiang Institute of Chinese Materia Medica and Ethnodrug, Urumqi 830002, China
Yu Sun: XinJiang Institute of Chinese Materia Medica and Ethnodrug, Urumqi 830002, China
Degang Qing: XinJiang Institute of Chinese Materia Medica and Ethnodrug, Urumqi 830002, China
Xiaoguang Jia: XinJiang Institute of Chinese Materia Medica and Ethnodrug, Urumqi 830002, China
Yingni Pan: School of Traditional Chinese Materia Medica 49#, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, China; Corresponding author. School of Traditional Chinese MateriaMedica28#, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, China. Tel.: +86 24 23986469; fax: +86 24 23986479.
Yue Hou: College of Life and Health Sciences, Northeastern University, Shenyang 110004, China; Corresponding author. College of Life and Health Sciences, Northeastern University, Shenyang 110004, China. Tel:. 86-24-23986475; fax: 86-24-31509368.

Journal volume & issue: Vol. 17
pp. 837 – 846

Abstract

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Oxidative stress and neuroinflammation are critical in the pathogenesis of neurodegenerative diseases. Extract of Coreopsis tinctoria Nutt. has been shown to ameliorate neurodegenerative diseases, potentially via inducing quinone oxidoreductase 1 (NQO1) and anti-neuroinflammation. The present study aimed to characterize the chemical profile and bioactive composition of the extract to identify the effective components responsible for the effects. Chromatography and spectra analysis yielded 26 constituents, including a new chalcone (compound 8). Bioassays showed that compounds 6, 9, 15, 17, 19, 21 and 22 significantly inhibited production of nitric oxide (NO) in N9 cells induced by lipopolysaccharides (LPS). Meanwhile compounds 1, 3, 6, 11, 19 and 20 exhibited significant NQO1 inducing activities in Hepa 1c1c7 cells. These results suggest that extract of C. tinctoria Nutt. contains bioactive components attenuating the progress of neurodegenerative diseases, thus, a valuable functional food for the prevention of neurodegenerative diseases.

Published in Journal of Functional Foods

ISSN: 1756-4646 (Print); 2214-9414 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Home economics: Nutrition. Foods and food supply
Website: https://www.journals.elsevier.com/journal-of-functional-foods

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