Effects of blue honeysuckle containing anthocyanin on anti-diabetic hypoglycemia and hyperlipidemia in ob/ob mice

Abstract

The purpose of the current study was to observe the anti-diabetic and anti-obesity effects of blue honeysuckle (BH; Lonicera caerulea L.) extracts on obese diabetic mice. BH extracts dose-dependently and significantly inhibited abnormal endocrine pancreas histopathological changes. Moreover, favorable anti-diabetic effects and non-alcoholic fatty liver disease, nephropathy, and hyperlipidemia refinement activities in BH extracts were shown to be dose dependent. Particularly, BH extract 200 mg/kg showed favorable modulatory activities on PPAR γ and AMPK in hepatic and adipose tissues as comparable to those of positive control, conjugated linoleic acid (CLA) administration. Results from the current study suggest that BH extracts could be a potential functional ingredient for anti-obesity and anti-diabetic effects through the inhibition of lipogenesis and hepatic glucose production by regulating lipid metabolism-related mRNA expressions.

Keywords

• Blue honeysuckle
• Anti-diabetic
• Non-alcoholic fatty liver disease
• Hyperlipidemia
• AMP-activated protein kinase